Han Xuesheng, Parker Tory L
dōTERRA International, LLC, 389 S. 1300 W., Pleasant Grove, UT 84062, USA.
Biochim Open. 2017 Mar 3;4:73-77. doi: 10.1016/j.biopen.2017.02.005. eCollection 2017 Jun.
The use of oregano () essential oil (OEO) has become popular in skin care products. However, scientific research regarding its effects on human skin cells is scarce. In this study, we investigated the biological activity of a commercially available OEO, which is high in carvacrol content, in a human skin cell disease model. OEO induced marked antiproliferative effects and significantly inhibited several inflammatory biomarkers, including monocyte chemoattractant protein 1 (MCP-1), vascular cell adhesion molecule 1 (VCAM-1), intracellular cell adhesion molecule 1 (ICAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG). OEO also significantly inhibited tissue remodeling biomarkers, namely collagen I, collagen III, epidermal growth factor receptor (EGFR), matrix metalloproteinase 1 (MMP-1), plasminogen activator inhibitor 1 (PAI-1), tissue inhibitor of metalloproteinase (TIMP) 1 and 2. An immunomodulatory biomarker, macrophage colony-stimulating factor (M-CSF), was also strongly inhibited by OEO treatment. In addition, OEO significantly modulated global gene expression and altered signaling pathways, many of which are critical in inflammation, tissue remodeling, and cancer signaling processes. These findings along with existing studies largely support the anti-inflammatory, tissue remodeling, immunomodulatory, and anticancer activities of OEO. In conclusion, this study provides the first evidence of the biological activity of OEO in human dermal fibroblasts. We suggest that OEO, with carvacrol as the major active component, is a promising candidate for use in skin care products with anti-inflammatory and anticancer properties.
牛至（）精油（OEO）在护肤品中的应用已变得流行。然而，关于其对人体皮肤细胞影响的科学研究却很匮乏。在本研究中，我们在人类皮肤细胞疾病模型中研究了一种市售的、香芹酚含量高的OEO的生物活性。OEO诱导了显著的抗增殖作用，并显著抑制了几种炎症生物标志物，包括单核细胞趋化蛋白1（MCP - 1）、血管细胞黏附分子1（VCAM - 1）、细胞间黏附分子1（ICAM - 1）、干扰素γ诱导蛋白10（IP - 10）、干扰素诱导的T细胞α趋化因子（I - TAC）以及γ干扰素诱导的单核因子（MIG）。OEO还显著抑制了组织重塑生物标志物，即胶原蛋白I、胶原蛋白III、表皮生长因子受体（EGFR）、基质金属蛋白酶1（MMP - 1）、纤溶酶原激活物抑制剂1（PAI - 1）、金属蛋白酶组织抑制剂（TIMP）1和2。一种免疫调节生物标志物，巨噬细胞集落刺激因子（M - CSF），也被OEO处理强烈抑制。此外，OEO显著调节整体基因表达并改变信号通路，其中许多在炎症、组织重塑和癌症信号传导过程中至关重要。这些发现与现有研究一起在很大程度上支持了OEO的抗炎、组织重塑、免疫调节和抗癌活性。总之，本研究提供了OEO在人皮肤成纤维细胞中生物活性的首个证据。我们认为以香芹酚为主要活性成分的OEO是具有抗炎和抗癌特性的护肤品的有前途的候选物。
