Han Xuesheng, Rodriguez Damian, Parker Tory L
dōTERRA International, LLC, 389 S. 1300 W, Pleasant Grove, UT 84062, USA.
Biochim Open. 2017 Feb 3;4:31-35. doi: 10.1016/j.biopen.2017.01.003. eCollection 2017 Jun.
Although frankincense essential oil (FREO) has become increasingly popular in skin care, research on its biological activities in human skin cells is scarce, if not completely absent. In the current study, we explored the biological activities of FREO in pre-inflamed human dermal fibroblasts by analyzing the levels of 17 important protein biomarkers pertinent to inflammation and tissue remodeling. FREO exhibited robust anti-proliferative activity in these skin cells. It also significantly inhibited collagen III, interferon gamma-induced protein 10, and intracellular cell adhesion molecule 1. We also studied its effect in regulating genome-wide gene expression. FREO robustly modulated global gene expression. Furthermore, Ingenuity Pathway Analysis showed that FREO affected many important signaling pathways that are closely related to inflammation, immune response, and tissue remodeling. This study provides the first evidence of the biological activities of FREO in human dermal fibroblasts. Consistent with existing studies in other models, the current study suggests that FREO possesses promising potential to modulate the biological processes of inflammation and tissue remodeling in human skin. Further research into the biological mechanisms of action of FREO and its major active components is recommended.
尽管乳香精油（FREO）在皮肤护理中越来越受欢迎，但关于其在人类皮肤细胞中的生物活性的研究即使不是完全没有，也是稀缺的。在当前的研究中，我们通过分析与炎症和组织重塑相关的17种重要蛋白质生物标志物的水平，探索了FREO在炎症前人类真皮成纤维细胞中的生物活性。FREO在这些皮肤细胞中表现出强大的抗增殖活性。它还显著抑制了III型胶原蛋白、干扰素γ诱导蛋白10和细胞内细胞粘附分子1。我们还研究了其在调节全基因组基因表达方面的作用。FREO有力地调节了整体基因表达。此外，通路分析表明FREO影响了许多与炎症、免疫反应和组织重塑密切相关的重要信号通路。本研究首次提供了FREO在人类真皮成纤维细胞中生物活性的证据。与其他模型中的现有研究一致，当前研究表明FREO具有调节人类皮肤炎症和组织重塑生物过程的潜在前景。建议进一步研究FREO及其主要活性成分的生物作用机制。
