Wang Bin, Li Ting, Niu Yan, Xiang Jie, Cheng Junjie, Liu Bo, Zhang Hui, Yan Tianyi, Kanazawa Susumu, Wu Jinglong
College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan, Shanxi, China.
Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
PLoS One. 2018 Feb 16;13(2):e0192532. doi: 10.1371/journal.pone.0192532. eCollection 2018.
Category-selective brain areas exhibit varying levels of neural activity to ipsilaterally presented stimuli. However, in face- and house-selective areas, the neural responses evoked by ipsilateral stimuli in the peripheral visual field remain unclear. In this study, we displayed face and house images using a wide-view visual presentation system while performing functional magnetic resonance imaging (fMRI). The face-selective areas (fusiform face area (FFA) and occipital face area (OFA)) exhibited intense neural responses to ipsilaterally presented images, whereas the house-selective areas (parahippocampal place area (PPA) and transverse occipital sulcus (TOS)) exhibited substantially smaller and even negative neural responses to the ipsilaterally presented images. We also found that the category preferences of the contralateral and ipsilateral neural responses were similar. Interestingly, the face- and house-selective areas exhibited neural responses to ipsilateral images that were smaller than the responses to the contralateral images. Multi-voxel pattern analysis (MVPA) was implemented to evaluate the difference between the contralateral and ipsilateral responses. The classification accuracies were much greater than those expected by chance. The classification accuracies in the FFA were smaller than those in the PPA and TOS. The closer eccentricities elicited greater classification accuracies in the PPA and TOS. We propose that these ipsilateral neural responses might be interpreted by interhemispheric communication through intrahemispheric connectivity of white matter connection and interhemispheric connectivity via the corpus callosum and occipital white matter connection. Furthermore, the PPA and TOS likely have weaker interhemispheric communication than the FFA and OFA, particularly in the peripheral visual field.
类别选择性脑区对同侧呈现的刺激表现出不同程度的神经活动。然而，在面孔和房屋选择性脑区中，外周视野中同侧刺激所诱发的神经反应仍不清楚。在本研究中，我们在进行功能磁共振成像（fMRI）时，使用宽视野视觉呈现系统展示面孔和房屋图像。面孔选择性脑区（梭状面孔区（FFA）和枕面孔区（OFA））对同侧呈现的图像表现出强烈的神经反应，而房屋选择性脑区（海马旁回位置区（PPA）和枕颞横沟（TOS））对同侧呈现的图像表现出明显较小甚至负性的神经反应。我们还发现，对侧和同侧神经反应的类别偏好相似。有趣的是，面孔和房屋选择性脑区对同侧图像的神经反应小于对侧图像。实施多体素模式分析（MVPA）以评估对侧和同侧反应之间的差异。分类准确率远高于随机预期。FFA中的分类准确率低于PPA和TOS中的分类准确率。在PPA和TOS中，越接近的偏心率引发越高的分类准确率。我们提出，这些同侧神经反应可能通过白质连接的半球内连接以及通过胼胝体和枕叶白质连接的半球间连接进行半球间通信来解释。此外，PPA和TOS可能比FFA和OFA具有更弱的半球间通信，特别是在外周视野中。
