Zhao J, Guo N, Zhang L, Wang L
a Department of Gynecology , the Affiliated Hospital of Qingdao University , Shandong , China.
b Department of Gynecology , the Women and Children's Hospital of Linyi , Shandong , China.
Br J Biomed Sci. 2018 Apr;75(2):66-70. doi: 10.1080/09674845.2017.1394051. Epub 2018 Feb 16.
CA125 has poor sensitivity and low specificity for detecting early ovarian cancer. Serum ferritin is elevated in many malignancies. We evaluated the performance of ferritin alone and in combination with CA125 as a diagnostic tool to detect epithelial ovarian cancer (EOC).
CA125 and ferritin were detected in the serum of 50 healthy control (HC), 50 women with benign gynaecological conditions and 124 women with EOC. The relationship between serum ferritin and CA125 and each of the clinicopathological parameters was assessed, and their diagnostic accuracy for discriminating ovarian cancer determined.
Serum ferritin and CA125 were higher in patients with EOC compared to HCs and patients with benign conditions (both p < 0.001). There was no relationship between levels of ferritin and CA125. Both ferritin and CA125 discriminated HC from EOC (p < 0.05), but ferritin showed better diagnostic accuracy than CA125 (p = 0.048). Ferritin was superior to CA125 in discrimination early EOC (p = 0.002), but in advanced stages, CA125 was superior (p = 0.026). A combination of ferritin and CA125 marginally increases the diagnostic accuracy to discriminate EOC from HCs.
Ferritin discriminates between HCs and EOC patients, especially in early stage disease. The combination of serum ferritin and CA125 provides the higher diagnostic accuracy to screen for EOC. Serum ferritin could serve as an EOC biomarker to complement the standard CA125 test.
CA125在检测早期卵巢癌时敏感性较差且特异性较低。血清铁蛋白在许多恶性肿瘤中都会升高。我们评估了单独使用铁蛋白以及将其与CA125联合作为检测上皮性卵巢癌（EOC）的诊断工具的性能。
检测了50名健康对照者（HC）、50名患有良性妇科疾病的女性以及124名患有EOC的女性血清中的CA125和铁蛋白。评估了血清铁蛋白与CA125之间的关系以及它们与每个临床病理参数之间的关系，并确定了它们鉴别卵巢癌的诊断准确性。
与HC和患有良性疾病的患者相比，EOC患者的血清铁蛋白和CA125更高（两者p均<0.001）。铁蛋白水平与CA125之间没有关系。铁蛋白和CA125都能将HC与EOC区分开来（p<0.05），但铁蛋白显示出比CA125更好的诊断准确性（p=0.048）。在鉴别早期EOC方面，铁蛋白优于CA125（p=0.002），但在晚期，CA125更具优势（p=0.026）。铁蛋白与CA125联合使用可略微提高从HC中鉴别EOC的诊断准确性。
铁蛋白能够区分HC和EOC患者，尤其是在疾病早期。血清铁蛋白与CA125联合使用可提供更高的诊断准确性来筛查EOC。血清铁蛋白可作为一种EOC生物标志物来补充标准的CA125检测。
