Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Curr Opin Immunol. 2018 Feb;50:112-116. doi: 10.1016/j.coi.2018.01.004. Epub 2018 Feb 14.
The immune system of the intestinal tract has the challenging task of recognizing and eliminating intestinal pathogens while maintaining tolerance to dietary and commensal antigens; therefore, it must be able to sense environmental cues within the intestine and mount suitable responses dictated by their pathogenic or nonpathogenic nature. The aryl hydrocarbon receptor (AHR) was originally characterized as a chemical sensor of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [12]. More recently, AHR has emerged as a major chemical sensor expressed in many intestinal immune cells that enables them to distinguish nutritional and microbial cues and is, therefore, important for development, maintenance and function of the intestinal immune system. In this review, we will highlight recent advances in our knowledge of the role of AHR signaling in intestinal innate lymphoid cells (ILC), T cells and B cells.
肠道免疫系统的艰巨任务是识别和消除肠道病原体，同时对饮食和共生抗原保持耐受；因此，它必须能够感知肠道内的环境线索，并根据其致病性或非致病性性质做出适当的反应。芳香烃受体 (AHR) 最初被描述为环境污染物 2,3,7,8-四氯二苯并对二恶英 (TCDD) 的化学传感器[12]。最近，AHR 已成为许多肠道免疫细胞中主要的化学传感器，使它们能够区分营养和微生物线索，因此对肠道免疫系统的发育、维持和功能很重要。在这篇综述中，我们将重点介绍 AHR 信号在肠道固有淋巴细胞 (ILC)、T 细胞和 B 细胞中的作用的最新研究进展。
