Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO, 63110, USA.
Semin Immunopathol. 2018 Jul;40(4):371-377. doi: 10.1007/s00281-018-0694-9. Epub 2018 Jun 27.
The intestinal immune system is challenged daily with the task of recognizing and eliminating pathogens while simultaneously tolerating dietary and commensal antigens. All components must effectively coordinate to differentiate a continual barrage of environmental cues and mount appropriate responses dependent on the nature of the stimuli encountered. Playing a pivotal role, the aryl hydrocarbon receptor (AHR) is a chemical sensor that detects both dietary and microbial cues and is important for development, maintenance, and function of several types of intestinal immune cells, particularly innate lymphoid cells (ILCs) and T cells. In this review, we will highlight recent advances in our knowledge of the role of AHR signaling in ILCs, T cells, B cells, and dendritic cells.
肠道免疫系统每天都面临着识别和消除病原体的任务，同时还要耐受饮食和共生抗原。所有的成分都必须有效地协调，以区分不断的环境线索，并根据遇到的刺激的性质做出适当的反应。芳香烃受体 (AHR) 作为一种化学传感器，起着关键作用，它可以检测饮食和微生物线索，对几种类型的肠道免疫细胞（特别是先天淋巴细胞 (ILC) 和 T 细胞）的发育、维持和功能都很重要。在这篇综述中，我们将重点介绍 AHR 信号在 ILCs、T 细胞、B 细胞和树突状细胞中的作用的最新研究进展。
