美国当代猪源 H1 流感病毒的抗原和遗传进化。
Antigenic and genetic evolution of contemporary swine H1 influenza viruses in the United States.
机构信息
Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, 1920 Dayton Avenue, PO Box 70, Ames, IA 50010, USA.
Department of Zoology, University of Cambridge, Downing St, Cambridge CB2 3EJ, UK.
出版信息
Virology. 2018 May;518:45-54. doi: 10.1016/j.virol.2018.02.006. Epub 2018 Feb 16.
Abstract
Several lineages of influenza A viruses (IAV) currently circulate in North American pigs. Genetic diversity is further increased by transmission of IAV between swine and humans and subsequent evolution. Here, we characterized the genetic and antigenic evolution of contemporary swine H1N1 and H1N2 viruses representing clusters H1-α (1A.1), H1-β (1A.2), H1pdm (1A.3.3.2), H1-γ (1A.3.3.3), H1-δ1 (1B.2.2), and H1-δ2 (1B.2.1) currently circulating in pigs in the United States. The δ1-viruses diversified into two new genetic clades, H1-δ1a (1B.2.2.1) and H1-δ1b (1B.2.2.2), which were also antigenically distinct from the earlier H1-δ1-viruses. Further characterization revealed that a few key amino acid changes were associated with antigenic divergence in these groups. The continued genetic and antigenic evolution of contemporary H1 viruses might lead to loss of vaccine cross-protection that could lead to significant economic impact to the swine industry, and represents a challenge to public health initiatives that attempt to minimize swine-to-human IAV transmission.
摘要
目前，几种甲型流感病毒（IAV）在北美猪群中流行。IAV 在猪与人之间传播并随后进化，进一步增加了遗传多样性。在这里，我们对代表当前在美国猪群中流行的 H1-α（1A.1）、H1-β（1A.2）、H1pdm（1A.3.3.2）、H1-γ（1A.3.3.3）、H1-δ1（1B.2.2）和 H1-δ2（1B.2.1）的当代 H1N1 和 H1N2 猪源病毒的遗传和抗原进化特征进行了描述。δ1 病毒分化为两个新的遗传分支，H1-δ1a（1B.2.2.1）和 H1-δ1b（1B.2.2.2），它们与早期的 H1-δ1 病毒在抗原上也有明显不同。进一步的特征分析表明，这些群体中抗原差异与少数关键氨基酸变化有关。当代 H1 病毒的持续遗传和抗原进化可能导致疫苗交叉保护的丧失，这可能给养猪业带来重大的经济影响，也代表了对试图最大限度减少猪源 IAV 向人类传播的公共卫生倡议的挑战。
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