Emerg Infect Dis. 2023 Jul;29(7):1397-1406. doi: 10.3201/eid2907.230165.
Influenza A viruses are a One Health threat because they can spill over between host populations, including among humans, swine, and birds. Surveillance of swine influenza virus in Hanoi, Vietnam, during 2013-2019 revealed gene pool enrichment from imported swine from Asia and North America and showed long-term maintenance, persistence, and reassortment of virus lineages. Genome sequencing showed continuous enrichment of H1 and H3 diversity through repeat introduction of human virus variants and swine influenza viruses endemic in other countries. In particular, the North American H1-δ1a strain, which has a triple-reassortant backbone that potentially results in increased human adaptation, emerged as a virus that could pose a zoonotic threat. Co-circulation of H1-δ1a viruses with other swine influenza virus genotypes raises concerns for both human and animal health.
甲型流感病毒对“同一健康”构成威胁，因为它们可以在宿主种群之间溢出，包括在人类、猪和鸟类之间。2013 年至 2019 年期间对越南河内的猪流感病毒进行监测显示，从亚洲和北美进口的猪的基因库得到了丰富，并且病毒谱系长期得到了维持、持续存在和重组。基因组测序显示，通过反复引入人类病毒变异株和其他国家流行的猪流感病毒，H1 和 H3 的多样性不断得到丰富。特别是具有三重重组骨架的北美 H1-δ1a 株，可能会增加人类的适应性，成为一种具有动物传染病威胁的病毒。H1-δ1a 病毒与其他猪流感病毒基因型的共同循环引起了人们对人类和动物健康的关注。
