Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Laureate Institute for Brain Research, Tulsa, OK, USA.
Mol Psychiatry. 2019 Jan;24(1):18-33. doi: 10.1038/s41380-018-0017-5. Epub 2018 Feb 16.
Depression and obesity are common conditions with major public health implications that tend to co-occur within individuals. The relationship between these conditions is bidirectional: the presence of one increases the risk for developing the other. It has thus become crucial to gain a better understanding of the mechanisms responsible for the intertwined downward physiological spirals associated with both conditions. The present review focuses specifically on shared biological pathways that may mechanistically explain the depression-obesity link, including genetics, alterations in systems involved in homeostatic adjustments (HPA axis, immuno-inflammatory activation, neuroendocrine regulators of energy metabolism including leptin and insulin, and microbiome) and brain circuitries integrating homeostatic and mood regulatory responses. Furthermore, the review addresses interventional opportunities and questions to be answered by future research that will enable a comprehensive characterization and targeting of the biological links between depression and obesity.
抑郁和肥胖是常见的病症，对公众健康有重大影响，而且往往在个体中同时存在。这两种病症之间存在相互关系：一种病症的存在会增加另一种病症的发病风险。因此，深入了解与这两种病症相关的生理螺旋式下降的机制变得至关重要。本综述专门关注可能从机制上解释抑郁和肥胖之间关联的共同生物学途径，包括遗传因素、参与体内平衡调节的系统改变（HPA 轴、免疫炎症激活、包括瘦素和胰岛素在内的能量代谢神经内分泌调节剂，以及微生物组）以及整合体内平衡和情绪调节反应的大脑回路。此外，本综述还讨论了干预机会和未来研究需要回答的问题，这些研究将有助于全面描述和针对抑郁和肥胖之间的生物学联系。
