Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China.
Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
J Invertebr Pathol. 2018 May;154:12-18. doi: 10.1016/j.jip.2018.02.012. Epub 2018 Feb 14.
The silkworm Bombyx mori (B. mori), a lepidopteran model organism, has become an important model for molecular biology researches with its genome completely sequenced. Silkworms confront different types of virus diseases, mainly including those caused by Bombyx mori nucleopolyhedrovirus (BmNPV), Bombyx mori densovirus type 1 (BmDNV-1), Bombyx mori bidesovirus (BmBDV) which was termed as Bombyx mori densovirus type 2 (BmDNV-2) or Bombyx mori parvo-like virus (BmPLV) before in sericulture. B. mori offers excellent models to study the molecular mechanisms of insect innate immune responses to viruses. A variety of molecules and pathways have been identified to be involved in the immune responses in the silkworm to viruses, such as the antimicrobial peptides, prophenoloxidase-activating system, apoptosis, ROS, small RNA and related molecules. Here in this review, we summarize the current research advances in molecules involved in silkworm anti-virus pathways. Moreover, taking BmNPV as an example, we proposed a schematic model of molecules and pathways involved in silkworm immune responses against virus infection. We hope this review can facilitate further study of antiviral mechanisms in silkworm, and provide a reference for virus diseases in other organisms.
家蚕（Bombyx mori）是鳞翅目模式生物，其基因组已完全测序，已成为分子生物学研究的重要模式生物。家蚕面临着多种类型的病毒病，主要包括由家蚕核型多角体病毒（BmNPV）、家蚕浓核病毒 1 型（BmDNV-1）、家蚕虹彩病毒（BmBDV）引起的病毒病，在养蚕业中，BmBDV 曾被称为家蚕浓核病毒 2 型（BmDNV-2）或家蚕细小病毒（BmPLV）。家蚕为研究昆虫先天免疫对病毒的分子机制提供了极好的模型。已经鉴定出多种参与家蚕抗病毒免疫反应的分子和途径，如抗菌肽、酚氧化酶激活系统、细胞凋亡、ROS、小 RNA 及相关分子。在本综述中，我们总结了参与家蚕抗病毒途径的分子的最新研究进展。此外，以 BmNPV 为例，我们提出了一个参与家蚕免疫反应抵抗病毒感染的分子和途径的示意图模型。我们希望本综述能促进家蚕抗病毒机制的进一步研究，并为其他生物的病毒病提供参考。
