Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Curr Opin Neurobiol. 2018 Aug;51:16-22. doi: 10.1016/j.conb.2018.01.013. Epub 2018 Feb 15.
A rich literature describes inhibitory innervation of pyramidal neurons in terms of the distinct inhibitory cell types that target the soma, axon initial segment, or dendritic arbor. Less attention has been devoted to how localization of inhibition to specific parts of the pyramidal dendritic arbor influences dendritic signal detection and integration. The effect of inhibitory inputs can vary based on their placement on dendritic spines versus shaft, their distance from the soma, and the branch order of the dendrite they inhabit. Inhibitory synapses are also structurally dynamic, and the implications of these dynamics depend on their dendritic location. Here we consider the heterogeneous roles of inhibitory synapses as defined by their strategic placement on the pyramidal cell dendritic arbor.
丰富的文献描述了锥体神经元的抑制性神经支配，涉及到靶向神经元胞体、轴突起始段或树突分支的不同抑制性细胞类型。然而，对于抑制性输入如何定位到特定的锥体树突分支区域影响树突信号检测和整合的机制，关注较少。抑制性输入的影响可以根据它们位于树突棘还是轴突上、与胞体的距离以及它们所在树突分支的顺序而有所不同。抑制性突触在结构上也是动态的，这些动态的影响取决于它们在树突上的位置。在这里，我们考虑了根据它们在锥体神经元树突上的位置而具有的不同功能的抑制性突触的异质性作用。
