Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave., Portland, OR 97227, USA.
Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave., Portland, OR 97227, USA.
Vaccine. 2018 Mar 14;36(12):1524-1527. doi: 10.1016/j.vaccine.2018.02.030. Epub 2018 Feb 15.
Reports of myocarditis and pericarditis following smallpox vaccination in adults suggested a need to assess inflammatory cardiac disease risk among adults who receive live viral vaccinations. From 1996 through 2007, among 416,629 vaccinated adults in the Vaccine Safety Datalink, we identified one probable pericarditis case and no cases of myocarditis in the 42 days following a live viral vaccination. Our self-controlled risk interval analysis found that, based on one case identified during the risk interval and 10 cases during the control interval, there is no increased risk of myopericarditis in the 42 days following vaccination (IRR, 0.57; 95% CI, 0.07, 4.51). Our study suggests that the occurrence of myopericarditis following live viral vaccination is rare with an estimated incidence of 0.24 per 100,000 vaccinated, which is not higher than the background rate and is much lower than the incidence rates reported following smallpox vaccination.
在成年人中，天花疫苗接种后出现心肌炎和心包炎的报告表明，有必要评估接受活病毒疫苗接种的成年人中炎症性心脏病的风险。在 1996 年至 2007 年间，在疫苗安全数据链中的 416629 名接种疫苗的成年人中，我们在接种活病毒疫苗后的 42 天内发现了 1 例疑似心包炎病例，没有心肌炎病例。我们的自我对照风险间隔分析发现，根据风险间隔期内确定的 1 例病例和对照间隔期内的 10 例病例，接种后 42 天内心肌心包炎的风险没有增加（IRR，0.57；95%CI，0.07，4.51）。我们的研究表明，活病毒疫苗接种后发生心肌心包炎的情况很少见，估计发病率为每 10 万人接种 0.24 例，这并不高于背景发生率，远低于天花疫苗接种后报告的发病率。
