Wichtowski Mateusz, Murawa Dawid, Kulcenty Katarzyna, Zaleska Karolina
Oncological and General Surgery Ward I, Greater Poland Cancer Center, Poznan, Poland.
Department of General and Minimally Invasive Surgery, Poland Baptism Monument Hospital, Gniezno, Poland.
Breast Care (Basel). 2017 Dec;12(6):409-414. doi: 10.1159/000479954. Epub 2017 Dec 3.
Breast cancer is the most common cause of skin metastases in women. The probability of their occurrence ranges from about 5% in the entire population to as much as 30% in the late stages of the disease. Although rarely life-threatening, they have a major impact on the quality of life of patients with this diagnosis, being the cause of pain, effusion, ulceration, infection, and psychological discomfort. Available methods of treatment, both local and systemic, often fail to provide adequate control of the disease. A particular challenge seems to be the treatment of those patients with cutaneous metastases who, due to the extent of their metastases, are not eligible for resection, in whom the possibility of radiation therapy has already been used, and in whom systemic therapy is ineffective or contraindicated. A new method providing the opportunity for effective treatment is electrochemotherapy (ECT). ECT combines electropulsation of tumor cells (by local application of electric pulses) and administration of antineoplastic drugs such as cisplatin or bleomycin (either intravenous or intratumoral). Several clinical studies have demonstrated that ECT provides safe, efficient, and non-invasive locoregional treatment for chest wall breast cancer recurrence.
乳腺癌是女性皮肤转移最常见的原因。其发生概率在整个人口中约为5%，在疾病晚期高达30%。虽然很少危及生命，但它们对患有这种疾病的患者的生活质量有重大影响，会导致疼痛、积液、溃疡、感染和心理不适。现有的局部和全身治疗方法往往无法充分控制疾病。对于那些因转移范围而不符合切除条件、已经接受过放射治疗且全身治疗无效或禁忌的皮肤转移患者的治疗似乎是一个特殊挑战。一种提供有效治疗机会的新方法是电化学疗法（ECT）。ECT将肿瘤细胞的电脉冲（通过局部施加电脉冲）与使用顺铂或博来霉素等抗肿瘤药物（静脉内或瘤内）相结合。多项临床研究表明，ECT为胸壁乳腺癌复发提供了安全、有效且非侵入性的局部区域治疗。
