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鼻咽癌与潜伏性颈淋巴结结核同时出现：对一个复杂病例的见解

A Simultaneous Presentation of Nasopharyngeal Carcinoma and Latent Cervical Tuberculosis: Insights into a Complex Case.

作者信息

Barcan Ingrid-Denisa, Closca Raluca Maria, Rakitovan Marina, Banta Andreea-Mihaela, Zara Flavia, Dema Sorin Adalbert, Virzob Claudia Raluca Balasa, Horhat Ioana Delia

机构信息

ENT Department, University of Medicine and Pharmacy "Victor Babes", 300041 Timisoara, Romania.

ENT Department, Emergency City Hospital, 300254 Timisoara, Romania.

出版信息

Diagnostics (Basel). 2025 Feb 4;15(3):357. doi: 10.3390/diagnostics15030357.

DOI:10.3390/diagnostics15030357
PMID:39941287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11817252/
Abstract

Tuberculosis infection triggers a chronic inflammatory response that can create a favorable environment for the development of cancer cells. Chronic inflammation can lead to DNA damage, increased cell proliferation, and impaired immune surveillance. Nasopharyngeal carcinoma is an aggressive malignant tumor with a very poor prognosis, despite the current oncology therapy. The case presents following clinical, imaging, and histopathological aspects, as well as the oncological follow-up of the patient over a period of 8 years. This paper presents the case of a 49-year-old patient diagnosed with cervical lymph node tuberculosis while biopsied for the diagnosis of nasopharyngeal carcinoma with cervical lymph node metastases. The overlap of this malignancy with an infection of mycobacterial etiology complicates the outcome of the disease even more, making treatment and prognosis difficult.

摘要

结核感染引发慢性炎症反应，可为癌细胞的发展创造有利环境。慢性炎症可导致DNA损伤、细胞增殖增加以及免疫监视受损。鼻咽癌是一种侵袭性恶性肿瘤，尽管有当前的肿瘤治疗方法，但其预后非常差。该病例呈现了以下临床、影像学和组织病理学方面的情况，以及患者8年期间的肿瘤学随访情况。本文介绍了一名49岁患者的病例，该患者在因鼻咽癌伴颈部淋巴结转移进行活检时被诊断为颈部淋巴结结核。这种恶性肿瘤与分枝杆菌病因感染的重叠使疾病的结局更加复杂，导致治疗和预后困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/7737cfea506a/diagnostics-15-00357-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/4f629cf39c88/diagnostics-15-00357-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/f2e1edca3d32/diagnostics-15-00357-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/3097080f329e/diagnostics-15-00357-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/e07a196ecd18/diagnostics-15-00357-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/01d2f94e97ef/diagnostics-15-00357-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/ca4fe933a009/diagnostics-15-00357-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/7737cfea506a/diagnostics-15-00357-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/4f629cf39c88/diagnostics-15-00357-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/f2e1edca3d32/diagnostics-15-00357-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/3097080f329e/diagnostics-15-00357-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/e07a196ecd18/diagnostics-15-00357-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/01d2f94e97ef/diagnostics-15-00357-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/ca4fe933a009/diagnostics-15-00357-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/7737cfea506a/diagnostics-15-00357-g007.jpg

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本文引用的文献

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Creating an interactive database for nasopharyngeal carcinoma management: applying machine learning to evaluate metastasis and survival.创建用于鼻咽癌管理的交互式数据库：应用机器学习评估转移和生存情况。
Front Oncol. 2024 Oct 7;14:1456676. doi: 10.3389/fonc.2024.1456676. eCollection 2024.
2
Coexistence of Tuberculosis and Malignancy in a Single Cervical Lymph Node: A Case Series.单个颈部淋巴结中结核病与恶性肿瘤的共存：病例系列
Ear Nose Throat J. 2024 Sep 12:1455613241276766. doi: 10.1177/01455613241276766.
3
Morphological and Immunohistochemical Aspects with Prognostic Implications and Therapeutic Targets of Primary Sinonasal Mucosal Melanoma: A Retrospective Study.
原发性鼻窦黏膜黑色素瘤的形态学和免疫组织化学特征及其预后意义和治疗靶点：一项回顾性研究
Cancers (Basel). 2024 Aug 16;16(16):2863. doi: 10.3390/cancers16162863.
4
Analysis on epidemiological and drug resistance characteristics of lymph node tuberculosis from Hunan province, China.中国湖南省淋巴结结核的流行病学和耐药特征分析。
Front Public Health. 2024 Jul 5;12:1432065. doi: 10.3389/fpubh.2024.1432065. eCollection 2024.
5
Tuberculosis - The master of disguise: A case of disseminated tuberculosis masquerading as metastatic cancer.结核病——伪装大师：一例伪装成转移性癌症的播散性结核病病例。
Tuberk Toraks. 2024 Jun;72(2):167-172. doi: 10.5578/tt.202402915.
6
A case of pulmonary tuberculosis that developed during nivolumab and ipilimumab treatment for pulmonary adenocarcinoma that recurred two months after completion of anti-tuberculous treatment.一例肺腺癌患者在接受 nivolumab 和 ipilimumab 治疗后出现肺结核，在抗结核治疗完成两个月后复发。
Chin Clin Oncol. 2024 Jun;13(3):43. doi: 10.21037/cco-23-153. Epub 2024 May 31.
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Ethno-geographic distribution and histopathological classification of nasopharyngeal carcinoma in a single center in Nepal.尼泊尔单中心的鼻咽癌的种族地理分布和组织病理学分类。
PLoS One. 2024 May 31;19(5):e0304371. doi: 10.1371/journal.pone.0304371. eCollection 2024.
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IDCases. 2024 Apr 16;36:e01968. doi: 10.1016/j.idcr.2024.e01968. eCollection 2024.
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