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鼻咽癌与潜伏性颈淋巴结结核同时出现:对一个复杂病例的见解

A Simultaneous Presentation of Nasopharyngeal Carcinoma and Latent Cervical Tuberculosis: Insights into a Complex Case.

作者信息

Barcan Ingrid-Denisa, Closca Raluca Maria, Rakitovan Marina, Banta Andreea-Mihaela, Zara Flavia, Dema Sorin Adalbert, Virzob Claudia Raluca Balasa, Horhat Ioana Delia

机构信息

ENT Department, University of Medicine and Pharmacy "Victor Babes", 300041 Timisoara, Romania.

ENT Department, Emergency City Hospital, 300254 Timisoara, Romania.

出版信息

Diagnostics (Basel). 2025 Feb 4;15(3):357. doi: 10.3390/diagnostics15030357.

Abstract

Tuberculosis infection triggers a chronic inflammatory response that can create a favorable environment for the development of cancer cells. Chronic inflammation can lead to DNA damage, increased cell proliferation, and impaired immune surveillance. Nasopharyngeal carcinoma is an aggressive malignant tumor with a very poor prognosis, despite the current oncology therapy. The case presents following clinical, imaging, and histopathological aspects, as well as the oncological follow-up of the patient over a period of 8 years. This paper presents the case of a 49-year-old patient diagnosed with cervical lymph node tuberculosis while biopsied for the diagnosis of nasopharyngeal carcinoma with cervical lymph node metastases. The overlap of this malignancy with an infection of mycobacterial etiology complicates the outcome of the disease even more, making treatment and prognosis difficult.

摘要

结核感染引发慢性炎症反应,可为癌细胞的发展创造有利环境。慢性炎症可导致DNA损伤、细胞增殖增加以及免疫监视受损。鼻咽癌是一种侵袭性恶性肿瘤,尽管有当前的肿瘤治疗方法,但其预后非常差。该病例呈现了以下临床、影像学和组织病理学方面的情况,以及患者8年期间的肿瘤学随访情况。本文介绍了一名49岁患者的病例,该患者在因鼻咽癌伴颈部淋巴结转移进行活检时被诊断为颈部淋巴结结核。这种恶性肿瘤与分枝杆菌病因感染的重叠使疾病的结局更加复杂,导致治疗和预后困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0365/11817252/4f629cf39c88/diagnostics-15-00357-g001.jpg

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