Assari Shervin
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Center for Research on Ethnicity, Culture and Health, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Adv Biomed Res. 2018 Jan 22;7:4. doi: 10.4103/2277-9175.223738. eCollection 2018.
Although the role of self-rated health (SRH) on all-cause mortality is known, we still do not know whether SRH predicts death due to specific causes (e.g., kidney disease). The current study aimed to compare Blacks and Whites on the association between SRH and mortality due to kidney diseases. A nationally representative sample of adults in the United States was used to provide generalizable results to the United States population.
The Americans' Changing Lives study is a nationally representative cohort, conducted from 1986-2011. The study followed 3361 Blacks ( = 1156) and Whites ( = 2205) for up to 25 years. The outcome was time to death due to kidney diseases, derived from death certificates and the National Death Index. Cox proportional hazards models were used to test whether race and baseline SRH interact on mortality due to kidney diseases.
In the pooled sample, poor SRH (odds ratio [OR] = 2.29, 95% confidence interval [CI] = 1.24-4.24) was associated with an increased risk of death due to kidney diseases over the follow-up period. Baseline SRH also showed a significant interaction with race on the outcome (OR = 0.49, 95% CI = 0.25-0.96), suggesting a stronger effect of SRH on deaths due to kidney diseases for Whites compared to Blacks. In race-specific models, poor SRH at baseline increased risk of death due to kidney diseases among Whites (OR = 2.23, 95% CI = 1.14-4.34) but not Blacks (OR = 1.14, 95% CI = 0.54-2.41).
Blacks and Whites differ regarding the predictive role of baseline SRH on death due to kidney diseases over time. Factors such as SRH better predict risk of mortality for Whites than for Blacks.
尽管自评健康状况(SRH)对全因死亡率的作用已为人所知,但我们仍不清楚SRH是否能预测特定原因(如肾病)导致的死亡。当前研究旨在比较黑人和白人在SRH与肾病导致的死亡率之间的关联。使用美国成年人的全国代表性样本,以便为美国人群提供可推广的结果。
“美国人生活变化”研究是一项全国代表性队列研究,于1986年至2011年进行。该研究对3361名黑人(n = 1156)和白人(n = 2205)进行了长达25年的随访。结局为肾病导致的死亡时间,数据来源于死亡证明和国家死亡指数。采用Cox比例风险模型来检验种族和基线SRH在肾病导致的死亡率方面是否存在交互作用。
在合并样本中,较差的SRH(优势比[OR]=2.29,95%置信区间[CI]=1.24 - 4.24)与随访期间肾病导致的死亡风险增加相关。基线SRH在结局方面也显示出与种族存在显著交互作用(OR = 0.49,95% CI = 0.25 - 0.96),这表明与黑人相比,SRH对白人因肾病导致的死亡影响更强。在种族特异性模型中,基线时较差的SRH增加了白人因肾病导致的死亡风险(OR = 2.23,95% CI = 1.14 - 4.34),但对黑人没有影响(OR = 1.14,95% CI = 0.54 - 2.41)。
随着时间推移,黑人和白人在基线SRH对肾病导致的死亡的预测作用方面存在差异。诸如SRH等因素对白人死亡率风险的预测比对黑人更好。