a National Organization for Drug Control & Research , Cairo , Egypt.
b Pharmacognosy Department, College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia.
Arch Physiol Biochem. 2019 May;125(2):128-135. doi: 10.1080/13813455.2018.1441315. Epub 2018 Feb 19.
Hyperlipidemia is an abnormality of lipid metabolism, characterized by an elevation of total cholesterol, triglyceride, and low density lipoprotein-cholesterol, and/or a decreasing of high density lipoprotein cholesterol in circulating levels. Hyperlipidemia has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases. Hyperlipidemia-associated lipid disorders are considered the cause of atherosclerotic cardiovascular disease. There has been a growing interest in natural products and their role in the maintenance and improvement of health and wellness. The cholesterol-lowering effect of dietary plants has been well studied and various natural products were shown to be helpful in lowering plasma cholesterol levels and encouraging safety profile. The main focus of this review is to describe what we know to date of natural products, along with their lipid-lowering mechanisms, which are either through inhibition of cholesterol absorption, inhibition of cholesterol synthesis or antioxidant mechanisms.
高脂血症是一种脂质代谢异常，其特征是循环中总胆固醇、甘油三酯和低密度脂蛋白胆固醇升高，和/或高密度脂蛋白胆固醇降低。高脂血症已被列为导致冠心病患病率和严重程度的最大危险因素之一。与高脂血症相关的脂质紊乱被认为是动脉粥样硬化性心血管疾病的原因。人们对天然产物及其在维持和改善健康方面的作用越来越感兴趣。膳食植物降低胆固醇的作用已得到充分研究，各种天然产物被证明有助于降低血浆胆固醇水平并具有安全性。本综述的主要重点是描述我们目前对天然产物的了解，以及它们的降脂机制，这些机制要么通过抑制胆固醇吸收，要么通过抑制胆固醇合成或抗氧化机制。
