Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan, 410006, China.
Cancer Research Institute, School of Basic Medical Science, Central South University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, Hunan, 410078, China.
Mol Cancer. 2018 Feb 19;17(1):61. doi: 10.1186/s12943-018-0812-2.
Glioma is one of the most prevalent types of primary intracranial carcinoma with varying malignancy grades I-IV and histological subtypes, including astrocytomas, glioblastoma multiform (GBM), oligodendrogliomas and mixed tumors. Glioma is characterized by rapid cell proliferation and angiogenesis, and the WHO grade IV glioblastoma, which is highly malignant with poor prognosis because GBM stem-like cells (GSCs) are resistant to conventional therapy and easily recrudescent, accounts for the majority of gliomas. Consequently, investigations exploring the accurate molecular mechanisms and reliable therapeutic targets for gliomas have drawn extensive attention.Based on the increasing amount of functional lncRNAs aberrantly expressed in glioma tissues and cell lines, lncRNAs might be critical for glioma initiation, progression and other malignant phenotypes. This review summarizes the latest insights into the lncRNA field and their functional roles in glioma, therefore evaluating the potential clinical applications of lncRNAs as prospective novel biomarkers and therapeutic targets.
脑胶质瘤是最常见的原发性颅内癌之一，其恶性程度不一，分为 I-IV 级和组织学亚型，包括星形细胞瘤、胶质母细胞瘤多形性（GBM）、少突胶质细胞瘤和混合瘤。脑胶质瘤的特征是细胞快速增殖和血管生成，而 WHO 分级为 IV 级的胶质母细胞瘤恶性程度高，预后差，因为胶质瘤干细胞（GSCs）对常规治疗具有抗性，且容易复发，占大多数脑胶质瘤。因此，对脑胶质瘤的准确分子机制和可靠治疗靶点的研究引起了广泛关注。基于在脑胶质瘤组织和细胞系中异常表达的大量功能性 lncRNA，lncRNA 可能对脑胶质瘤的发生、发展和其他恶性表型至关重要。本综述总结了 lncRNA 领域的最新研究进展及其在脑胶质瘤中的功能作用，从而评估 lncRNA 作为有前途的新型生物标志物和治疗靶点的潜在临床应用。
