Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Center for RNA Interference and Non-coding RNA, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Curr Opin Genet Dev. 2018 Feb;48:8-15. doi: 10.1016/j.gde.2017.10.004. Epub 2017 Oct 17.
Sequencing technology has facilitated a new era of cancer research, especially in cancer genomics. Using next-generation sequencing, thousands of long noncoding RNAs (lncRNAs) have been identified as abnormally altered in the cancer genome or differentially expressed in tumor tissues. These lncRNAs are associated with imbalanced gene regulation and aberrant biological processes that contribute to malignant transformation. The functions and therapeutic potential of cancer-related lncRNAs have attracted considerable interest in the past few years. Although few lncRNAs have been well-characterized, researchers have recently made impressive progress in understanding lncRNAs and their novel functions, such as regulation of gene expression, metabolism and DNA repair. These latest findings reinforce the crucial roles of lncRNAs in cancer initiation and development, as well as their possible clinical applications.
测序技术促进了癌症研究的新时代，尤其是在癌症基因组学领域。使用下一代测序技术，已经发现数千个长非编码 RNA（lncRNA）在癌症基因组中异常改变或在肿瘤组织中差异表达。这些 lncRNA 与基因调控失衡和异常的生物学过程有关，这些过程导致恶性转化。过去几年，癌症相关 lncRNA 的功能和治疗潜力引起了广泛关注。尽管少数 lncRNA 已经得到了很好的描述，但研究人员最近在理解 lncRNA 及其新功能方面取得了令人瞩目的进展，如基因表达、代谢和 DNA 修复的调控。这些最新发现强调了 lncRNA 在癌症发生和发展中的关键作用，以及它们在临床上的应用潜力。
