实施快速甲型/乙型流感病毒和呼吸道合胞病毒直接分子检测可改善急诊科对儿科患者使用奥司他韦的情况。
Implementation of a rapid influenza A/B and RSV direct molecular assay improves emergency department oseltamivir use in paediatric patients.
作者信息
Mitchell Stephanie L, Chang Yeh-Chung, Feemster Kristen, Cárdenas Ana María
机构信息
Clinical Microbiology Laboratory, Children's Hospital of Pittsburgh of UPMC and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Pediatrics, The Perelman School of Medicine, Philadelphia, PA, USA.
出版信息
J Med Microbiol. 2018 Mar;67(3):358-363. doi: 10.1099/jmm.0.000676. Epub 2018 Jan 10.
PURPOSE
Influenza A virus (FluA), influenza B virus (FluB) and respiratory syncytial virus (RSV) illnesses increase hospitalizations during seasonal epidemics.
METHODOLOGY
To determine the utility of the Simplexa FluA/B & RSV Direct Assay (Direct Flu/RSV) and its impact on oseltamivir use, we offered this assay to emergency department (ED) patients with influenza-like illness.
RESULTS
Utilization of the Direct Flu/RSV provided a turnaround time (TAT) of 2 hours. Compared to the flu season prior to implementation of the Direct Flu/RSV, clinicians were more likely to prescribe 5 days of oseltamivir therapy for Direct Flu/RSV-positive patients in comparison to those with a negative test.
CONCLUSIONS
Use of Direct Flu/RSV provides results rapidly, which leads to more appropriate use of oseltamivir. The ease of use of this assay and quick TAT allows for prompt decision-making, which is essential for patient care and effective disease control during the influenza season.
目的
甲型流感病毒（FluA）、乙型流感病毒（FluB）和呼吸道合胞病毒（RSV）感染在季节性流行期间会增加住院率。
方法
为了确定Simplexa FluA/B & RSV直接检测法（Direct Flu/RSV）的效用及其对奥司他韦使用的影响，我们为急诊科（ED）患有流感样疾病的患者提供了该检测法。
结果
Direct Flu/RSV检测法的周转时间（TAT）为2小时。与实施Direct Flu/RSV检测法之前的流感季节相比，与检测结果为阴性的患者相比，临床医生更有可能为Direct Flu/RSV检测呈阳性的患者开具5天的奥司他韦治疗方案。
结论
使用Direct Flu/RSV检测法能快速得出结果，从而更合理地使用奥司他韦。该检测法使用简便且周转时间短，有助于迅速做出决策，这对于流感季节的患者护理和有效疾病控制至关重要。
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