1Physical Activity Epidemiology Laboratory,Exercise Psychology Laboratory,Department of Health,Exercise Science and Recreation Management,University of Mississippi,Oxford, MS 38677,USA.
2Department of Epidemiology and Biostatistics and the Cancer Prevention and Control Program,University of South Carolina,Columbia,SC 29208,USA.
Br J Nutr. 2018 Mar;119(5):552-558. doi: 10.1017/S0007114517003804. Epub 2018 Jan 24.
The objective of this study was to examine the association between dietary inflammatory potential and memory and cognitive functioning among a representative sample of the US older adult population. Cross-sectional data from the 2011-2012 and 2013-2014 National Health and Nutrition Examination Survey were utilised to identify an aggregate sample of adults 60-85 years of age (n 1723). Dietary inflammatory index (DII®) scores were calculated using 24-h dietary recall interviews. Three memory-related assessments were employed, including the Consortium to Establish a Registry for Alzheimer's disease (CERAD) Word Learning subset, the Animal Fluency test and the Digit Symbol Substitution Test (DSST). Inverse associations were observed between DII scores and the different memory parameters. Episodic memory (CERAD) (b adjusted=-0·39; 95 % CI -0·79, 0·00), semantic-based memory (Animal Fluency Test) (b adjusted=-1·18; 95 % CI -2·17, -0·20) and executive function and working-memory (DSST) (b adjusted=-2·80; 95 % CI -5·58, -0·02) performances were lowest among those with the highest mean DII score. Though inverse relationships were observed between DII scores and memory and cognitive functioning, future work is needed to further explore the neurobiological mechanisms underlying the complex relationship between inflammation-related dietary behaviour and memory and cognition.
本研究旨在探讨美国老年人群体中饮食炎症潜能与记忆和认知功能之间的关系。本研究利用了 2011-2012 年和 2013-2014 年全国健康与营养调查的横断面数据，确定了一个 60-85 岁成年人的综合样本（n=1723）。采用 24 小时膳食回顾访谈计算饮食炎症指数（DII®）评分。采用三种与记忆相关的评估方法，包括阿尔茨海默病建立登记册联盟（CERAD）单词学习子测试、动物流畅性测试和数字符号替代测试（DSST）。DII 评分与不同记忆参数之间存在负相关。情节记忆（CERAD）（b 调整值=-0·39；95 % CI -0·79, 0·00）、语义记忆（动物流畅性测试）（b 调整值=-1·18；95 % CI -2·17, -0·20）和执行功能和工作记忆（DSST）（b 调整值=-2·80；95 % CI -5·58, -0·02）的表现最低，这些都是在 DII 得分最高的人群中。尽管 DII 评分与记忆和认知功能之间存在负相关关系，但仍需要进一步研究以探索炎症相关饮食行为与记忆和认知之间复杂关系的神经生物学机制。
