p13 可预防帕金森病。
p13 protects against Parkinson's disease.
机构信息
VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
出版信息
EMBO Rep. 2018 Mar;19(3). doi: 10.15252/embr.201845900. Epub 2018 Feb 19.
Abstract
Mitochondrial dysfunction is thought to contribute to Parkinson's disease progression, and factors that can overcome mitochondrial defects could potentially be used to combat the disease and prevent neuronal death. In this issue, Inoue 1 report that reduction of p13, a mitochondrial protein that inhibits complex I assembly, rescues the cellular and behavioral defects of Parkinson's disease models. This work suggests that stabilizing the mitochondrial electron transport chain may be beneficial in the context of Parkinson's disease.
摘要
线粒体功能障碍被认为是导致帕金森病进展的原因之一，因此能够克服线粒体缺陷的因素可能被用于对抗这种疾病和防止神经元死亡。在本期杂志中，Inoue 1 报道称，减少一种抑制复合物 I 组装的线粒体蛋白 p13 可以挽救帕金森病模型的细胞和行为缺陷。这项工作表明，稳定线粒体电子传递链可能对帕金森病有益。
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EMBO Rep. 2018 Mar;19(3). doi: 10.15252/embr.201744860. Epub 2018 Jan 25.
2
Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.线粒体蛋白质相互作用图谱鉴定呼吸链功能的调节因子。
Mol Cell. 2016 Aug 18;63(4):621-632. doi: 10.1016/j.molcel.2016.06.033. Epub 2016 Aug 4.
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p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice.胰腺β细胞中p13的过表达改善了高脂喂养小鼠的2型糖尿病。
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