修剪得很短：PNLDC1 在小鼠精子发生过程中 piRNA 的成熟过程中是必需的。
Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis.
机构信息
Institute of Molecular Biology, Biology of non-coding RNA, Mainz, Germany.
出版信息
EMBO Rep. 2018 Mar;19(3). doi: 10.15252/embr.201845824. Epub 2018 Feb 19.
Abstract
Transposon silencing within the germ line requires the proper processing of piRNA intermediates. However, the enzyme that is required for piRNA 3′ end maturation in vertebrates remained enigmatic. Nishimura 1 in this issue of and two independent studies 2, 3 now identified PNLDC1 as the exonuclease that is responsible for piRNA 3′ end processing and transposon silencing during mouse spermatogenesis. Together, these studies establish PNLDC1 as the piRNA 3′ end trimmer in mouse.
摘要
转座子沉默在生殖细胞中需要 piRNA 中间产物的正确加工。然而，脊椎动物中用于 piRNA 3'端成熟的酶仍然是个谜。Nishimura 在本期的研究 和两项独立的研究 2,3 中，现在确定 PNLDC1 是外切酶，负责小鼠精子发生过程中的 piRNA 3'端加工和转座子沉默。这些研究共同确定 PNLDC1 为小鼠中的 piRNA 3'端修剪酶。
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本文引用的文献
1
PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.PNLDC1，一种小鼠前 piRNA 修剪酶，对于减数分裂和减数分裂后雄性生殖细胞的发育是必需的。
EMBO Rep. 2018 Mar;19(3). doi: 10.15252/embr.201744957. Epub 2018 Feb 14.
2
PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice.PNLDC1对于小鼠精子发生过程中的piRNA 3'端修剪和转座子沉默至关重要。
Nat Commun. 2017 Oct 10;8(1):819. doi: 10.1038/s41467-017-00854-4.
3
An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice.PNLDC1在小鼠piRNA 3'端修剪及雄性生育能力中起关键作用。
Cell Res. 2017 Nov;27(11):1392-1396. doi: 10.1038/cr.2017.125. Epub 2017 Oct 10.
4
The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans.核糖核酸酶PARN-1修剪piRNA的3'末端以促进秀丽隐杆线虫的转录组监测。
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