Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, Maryland 20892, USA;
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Genes Dev. 2024 Aug 20;38(13-14):597-613. doi: 10.1101/gad.351934.124.
Small RNAs base pair with and regulate mRNA translation and stability. For both bacterial small regulatory RNAs and eukaryotic microRNAs, association with partner proteins is critical for the stability and function of the regulatory RNAs. We review the mechanisms for degradation of these RNAs: displacement of the regulatory RNA from its protein partner (in bacteria) or destruction of the protein and its associated microRNAs (in eukaryotes). These mechanisms can allow specific destruction of a regulatory RNA via pairing with a decay trigger RNA or function as global off switches by disrupting the stability or function of the protein partner.
小 RNA 与 mRNA 结合并调节其翻译和稳定性。对于细菌中的小调控 RNA 和真核生物中的 microRNA，与伴侣蛋白的结合对于调控 RNA 的稳定性和功能至关重要。我们回顾了这些 RNA 降解的机制：从其蛋白伴侣上置换调控 RNA（在细菌中）或破坏蛋白及其相关的 microRNA（在真核生物中）。这些机制可以通过与降解触发 RNA 配对特异性地破坏调控 RNA，或者通过破坏蛋白伴侣的稳定性或功能作为全局关闭开关。
