Division of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science.
Health Administration Center, Shiga University of Medical Science.
J Atheroscler Thromb. 2018 Oct 1;25(10):1009-1021. doi: 10.5551/jat.42127. Epub 2018 Feb 16.
We aimed to investigate the association between reduced lung function and cerebral small vessel diseases via cranial magnetic resonance imaging (MRI) in the cross-sectional study of the general Japanese population.
We recruited participants aged ≥40 years from the general population of a single city in Japan. We clarified the comorbidities and treatments, smoking habits, second-hand smoke exposure, current alcohol consumption, education level, exercise habits, and occupation. The pulmonary function test was performed to assess the forced expiratory volume in 1 second (FEV) % predicted and forced vital capacity (FVC) % predicted values. Cranial MRI was performed to evaluate the white matter lesions (WMLs) and lacunar infarcts. We examined the association of the WMLs and lacunar infarcts with a 1-standard deviation (SD) lower in the FEV % predicted and FVC % predicted, on the basis of the smoking status.
A total of 473 men were examined. The association of WMLs and lacunar infarcts with the spirometry-based indices were significant only in never smokers. The association between lung function impairment and cerebral small vessel disease did not change after further adjusting for second-hand smoke exposure.
In a community-based sample of Japanese men, we found an association between reduced lung function and WMLs and lacunar infarcts in never smokers.
通过对日本某一城市的普通人群进行横断面研究，我们旨在通过颅磁共振成像（MRI）来研究肺功能降低与脑小血管疾病之间的关联。
我们招募了年龄≥40 岁的来自日本某一城市普通人群的参与者。我们明确了合并症和治疗、吸烟习惯、二手烟暴露、当前饮酒量、教育程度、运动习惯和职业。进行肺功能检查以评估 1 秒用力呼气量（FEV）%预计值和用力肺活量（FVC）%预计值。进行颅 MRI 以评估脑白质病变（WML）和腔隙性梗死。我们根据吸烟状况，检查了 WML 和腔隙性梗死与 FEV%预计值和 FVC%预计值降低 1 个标准差（SD）之间的关联。
共检查了 473 名男性。WML 和腔隙性梗死与基于肺活量计的指标之间的关联仅在从不吸烟者中具有显著性。在进一步调整二手烟暴露后，肺功能损害与脑小血管疾病之间的关联并未改变。
在日本男性的社区样本中，我们发现从不吸烟者的肺功能降低与 WML 和腔隙性梗死之间存在关联。
