Khanam A, Akter Q S, Karim F, Zannat M R
Dr Afruza Khanam, Assistant Professor, Department of Physiology, Marks Medical College, Dhaka, Bangladesh; E-mail:
Mymensingh Med J. 2018 Jan;27(1):103-107.
The patient with diabetes mellitus (DM) and its complication is increasing in our country and all over the world. There is also significant increase in the prevalence of erythrocyte glucose-6-phosphate dehydrogenase (eG6PD) deficiency in the men with longer duration of diabetes mellitus. To assess the eG6PD in type 2 diabetes male subjects to observe their enzyme status. This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from January 2011 to December 2011. Sixty male subjects with type 2 diabetes mellitus were selected with the age ranging from 40 to 60 years. Out of diabetic subjects, 30 (thirty) were with controlled (B1) and other 30 (thirty) with uncontrolled (B2) type 2 diabetes mellitus were selected from Outpatient Department of BIRDEM Hospital by random basis. And 30 age-matched, healthy non-diabetic male subjects were considered as control group for comparison. Erythrocyte G6PD level was measured by spectrophotometric method. Fasting Blood Glucose (FBG), HbA1c were measured by standard laboratory techniques in the laboratory of BIRDEM and Armed Forces Institute of Pathology (AFIP), Dhaka Cantonment, Dhaka. For statistical analysis unpaired Student's 't' test was performed. The result was expressed as Mean±SD among the groups. In this study, eG6PD level was significantly lower in both the study groups. This study concludes that eG6PD level decreases in male with diabetes mellitus.
我国及全球糖尿病及其并发症患者数量都在增加。糖尿病病程较长的男性中，红细胞葡萄糖-6-磷酸脱氢酶（eG6PD）缺乏症的患病率也显著上升。为评估2型糖尿病男性受试者的eG6PD，以观察其酶状态。这项横断面研究于2011年1月至2011年12月在孟加拉国达卡达卡医学院生理学系进行。选取了60名年龄在40至60岁之间的2型糖尿病男性受试者。在糖尿病受试者中，随机从BIRDEM医院门诊部选取30名（三十名）2型糖尿病得到控制（B1）的患者和另外30名（三十名）2型糖尿病未得到控制（B2）的患者。另外选取30名年龄匹配的健康非糖尿病男性受试者作为对照组进行比较。采用分光光度法测量红细胞G6PD水平。空腹血糖（FBG）、糖化血红蛋白（HbA1c）在达卡达卡 cantonment的BIRDEM和武装部队病理研究所（AFIP）实验室通过标准实验室技术进行测量。进行统计学分析时采用非配对学生t检验。结果以各组的均值±标准差表示。在本研究中，两个研究组的eG6PD水平均显著降低。本研究得出结论，糖尿病男性的eG6PD水平会降低。
