Eva H, Akter Q S, Alam M K
Dr Hossneara Eva, Associate Professor & Head, Department of Physiology, Brahmanbaria Medical College, Brahmanbaria, Bangladesh; E-mail:
Mymensingh Med J. 2020 Apr;29(2):357-360.
Association of increased diabetes related complication and higher glycemic status in patients with type 2 diabetes mellitus (DM) has been well recognized. This cross sectional study was carried out to assess serum zinc (Zn) level and its relationship to glycemic status in type 2 DM patients and conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from July 2014 to June 2015. Fifty (50) type 2 diabetic subjects with age ranging from 40 to 55 years were study group and fifty healthy subjects matched by ages and BMI were control group. Study population was chosen from Bangladesh Institute of Research for Diabetic Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka, Bangladesh. Glycated hemoglobin (HbA1c) and fasting serum glucose (FSG) levels were estimated in the laboratory of the Department of Biochemistry, BIRDEM General Hospital, Dhaka, Bangladesh. Serum Zn level was estimated by flame atomic absorption spectrophotometry. For statistical analysis unpaired Student's 't' test was performed. In this study, mean serum zinc level was significantly (p<0.001) lower in patients than that of control group. On correlation analysis, serum Zn level showed significant negative correlation with FSG and HbA1C levels in type 2 diabetic patients. The results conclude that serum Zn level was reduced in DM which was higher with glycemic status of this disease.
2型糖尿病（DM）患者中糖尿病相关并发症增加与血糖水平升高之间的关联已得到充分认识。本横断面研究旨在评估2型糖尿病患者的血清锌（Zn）水平及其与血糖状态的关系，于2014年7月至2015年6月在孟加拉国达卡达卡医学院生理学系进行。50名年龄在40至55岁之间的2型糖尿病受试者为研究组，50名年龄和体重指数相匹配的健康受试者为对照组。研究人群选自孟加拉国达卡糖尿病、内分泌和代谢紊乱研究所（BIRDEM）总医院。糖化血红蛋白（HbA1c）和空腹血糖（FSG）水平在孟加拉国达卡BIRDEM总医院生物化学系实验室进行测定。血清锌水平通过火焰原子吸收分光光度法测定。进行统计学分析时采用了非配对学生t检验。在本研究中，患者的平均血清锌水平显著低于对照组（p<0.001）。相关性分析显示，2型糖尿病患者的血清锌水平与FSG和HbA1C水平呈显著负相关。结果表明，糖尿病患者血清锌水平降低，且随着该疾病血糖状态的升高而降低。
