Karim F, Akter Q S, Khanom A, Haque S, Nahar S
Dr Fayeza Karim, Associate Professor and Head, Department of Physiology, Aichi Medical College, Dhaka, Bangladesh; E-mail:
Mymensingh Med J. 2020 Jul;29(3):659-663.
The patient with diabetes mellitus and its complication is increasing in our country and all over the world. Altered platelet morphology and function have been reported in patient with DM. Mean platelet volume has been suggested as a newly emerging and independent risk marker for atherothrombosis and cardiovascular disease. The present study was carried out to assess the mean platelet volume in subjects with type 2 diabetes mellitus. The present study was a cross sectional analytic study and conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from July 2013 to June 2014. A total number of 200 adult male subjects were selected with age ranging from 40 to 60 years. Among them, 100 subjects with type 2 diabetes mellitus were included in the case (Group B) and 100 healthy subjects with same age range were considered as control (Group A) for comparison. The subjects were selected from BIRDEM hospital Dhaka and personal contact from different areas of Dhaka city on the basis of exclusion and inclusion criteria. The study parameter was mean platelet volume and was measured in the Department of Hematology of BIRDEM hospital, Dhaka. The data were collected and recorded in pre-designed structured questionnaire by the researcher herself. For statistical analyses unpaired Student's 't' test was performed as applicable using SPSS for windows version 19. In this study, mean platelet volume was significantly (p<0.001) higher in the case group than that of control group. Therefore, estimation of mean platelet volume might be beneficial for prediction of future cardiovascular risk in adult diabetic male.
我国乃至全球糖尿病及其并发症患者的数量都在不断增加。糖尿病患者中已出现血小板形态和功能的改变。平均血小板体积已被视为动脉粥样硬化血栓形成和心血管疾病新出现的独立风险标志物。本研究旨在评估2型糖尿病患者的平均血小板体积。本研究为横断面分析研究，于2013年7月至2014年6月在孟加拉国达卡达卡医学院生理学系开展。共选取200名年龄在40至60岁之间的成年男性受试者。其中，100名2型糖尿病患者被纳入病例组（B组），100名年龄范围相同的健康受试者被视为对照组（A组）用于比较。受试者根据排除和纳入标准从达卡的BIRDEM医院及达卡市不同地区的个人联系中选取。研究参数为平均血小板体积，在达卡BIRDEM医院血液学系进行测量。数据由研究者本人收集并记录在预先设计的结构化问卷中。统计分析时，视情况使用适用于Windows版本19的SPSS软件进行非配对学生t检验。在本研究中，病例组的平均血小板体积显著高于对照组（p<0.001）。因此，估计平均血小板体积可能有助于预测成年男性糖尿病患者未来的心血管风险。
