University of Calgary, Department of Biochemistry and Molecular Biology, Calgary, T2N 1N4, Canada.
University of Calgary, Department of Biological Sciences, Calgary, T2N 1N4, Canada.
Sci Rep. 2018 Feb 19;8(1):3308. doi: 10.1038/s41598-018-21585-6.
Modifiable lifestyle factors, including exercise and activity energy expenditure (AEE), may attenuate the unfavorable health effects of obesity, such as risk factors of metabolic syndrome (MetS). However, the underlying mechanisms are not clear. In this study we sought to investigate whether the metabolite profiles of MetS and adiposity assessed by body mass index (BMI) and central obesity are inversely correlated with AEE and physical activity. We studied 35 men and 47 women, aged 30-60 years, using doubly labeled water to derive AEE and the Sedentary Time and Activity Reporting Questionnaire (STAR-Q) to determine the time spent in moderate and vigorous physical activity. Proton nuclear magnetic resonance spectroscopy was used for serum metabolomics analysis. Serine and glycine were found in lower concentrations in participants with more MetS risk factors and greater adiposity. However, serine and glycine concentrations were higher with increasing activity measures. Metabolic pathway analysis and recent literature suggests that the lower serine and glycine concentrations in the overweight/obese state could be a consequence of serine entering de novo sphingolipid synthesis. Taken together, higher levels of AEE and physical activity may play a crucial part in improving metabolic health in men and women with and without MetS risk factors.
可改变的生活方式因素，包括运动和活动能量消耗（AEE），可能会减轻肥胖对健康的不利影响，如代谢综合征（MetS）的危险因素。然而，其潜在机制尚不清楚。在这项研究中，我们试图研究通过体重指数（BMI）和中心性肥胖评估的 MetS 和肥胖的代谢物谱是否与 AEE 和体力活动呈负相关。我们研究了 35 名男性和 47 名女性，年龄在 30-60 岁之间，使用双标记水来计算 AEE，使用久坐时间和活动报告问卷（STAR-Q）来确定进行中等强度和剧烈体力活动的时间。质子核磁共振波谱用于血清代谢组学分析。研究发现，具有更多 MetS 危险因素和更大肥胖的参与者的丝氨酸和甘氨酸浓度较低。然而，随着活动量的增加，丝氨酸和甘氨酸的浓度也随之升高。代谢途径分析和最近的文献表明，超重/肥胖状态下丝氨酸和甘氨酸浓度较低可能是丝氨酸进入从头鞘脂合成的结果。综上所述，较高水平的 AEE 和体力活动可能在改善有和没有 MetS 危险因素的男性和女性的代谢健康方面发挥关键作用。
