Maréchal René, Ghachem Ahmed, Prud'homme Denis, Rabasa-Lhoret Rémi, Dionne Isabelle J, Brochu Martin
Research Centre on Aging, CIUSSS de l'Estrie-CHUS, Sherbrooke, QC J1H 4C4, Canada.
Faculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Appl Physiol Nutr Metab. 2021 Apr;46(4):389-396. doi: 10.1139/apnm-2020-0607. Epub 2020 Oct 20.
Menopause transition is associated with detrimental changes in physical activity, body composition, and metabolic profile. Although physical activity energy expenditure (PAEE) is inversely associated with metabolic syndrome (MetS) in individuals at higher risk of cardiovascular disease, the association is unknown in low-risk individuals. The aim of the study was to investigate the association between PAEE and MetS (prevalence and severity) in inactive overweight or obese postmenopausal women with a low Framingham Risk Score (<10%). Cross-sectional data of 126 participants were divided into quartiles based on PAEE (Quartile (Q)1 = lowest PAEE) while fat-free mass (FFM) and fat mass were measured by dual-energy X-ray absorptiometry. MetS prevalence was significantly different between Q1 and Q4 (37.9% vs 13.3%, = 0.03). After controlling for potential confounders, MetS severity was negatively associated with PAEE (B = -0.057, < 0.01) and positively with FFM (B = 0.038, < 0.001). Moderation analyses indicated that a greater FFM exacerbated the association between PAEE and MetS severity in Q1 and Q2 (PAEE × FFM; B = -0.004; = 0.1). Our results suggest that displaying a low FRS and lower PAEE increase MetS prevalence and severity. In addition, greater FFM interacts with lower PAEE to worsens MetS severity, while higher PAEE lessened this effect. Inactive individuals displaying higher daily PAEE also have a lower MetS prevalence. Greater FFM is associated with a worse MetS severity where a higher PAEE mitigated this deleterious effect in our cohort.
绝经过渡与身体活动、身体成分和代谢状况的有害变化相关。尽管身体活动能量消耗（PAEE）与心血管疾病高风险个体的代谢综合征（MetS）呈负相关，但在低风险个体中这种关联尚不清楚。本研究的目的是调查PAEE与低弗雷明汉风险评分（<10%）的不活动超重或肥胖绝经后女性的MetS（患病率和严重程度）之间的关联。126名参与者的横断面数据根据PAEE分为四分位数（四分位数（Q）1 = 最低PAEE），同时通过双能X线吸收法测量无脂肪量（FFM）和脂肪量。Q1和Q4之间的MetS患病率有显著差异（37.9%对13.3%，P = 0.03）。在控制潜在混杂因素后，MetS严重程度与PAEE呈负相关（B = -0.057，P < 0.01），与FFM呈正相关（B = 0.038，P < 0.001）。调节分析表明，在Q1和Q2中，较高的FFM加剧了PAEE与MetS严重程度之间的关联（PAEE×FFM；B = -0.004；P = 0.1）。我们的结果表明，低FRS和较低的PAEE会增加MetS的患病率和严重程度。此外，较高的FFM与较低的PAEE相互作用会加重MetS严重程度，而较高的PAEE会减轻这种影响。日常PAEE较高的不活动个体的MetS患病率也较低。在我们的队列中，较高的FFM与较差的MetS严重程度相关，而较高的PAEE减轻了这种有害影响。
