Handtke Stefan, Steil Leif, Greinacher Andreas, Thiele Thomas
Institut für Immunologie und Transfusionsmedizin, Greifswald, Germany.
Interfakultäres Institut für Funktionelle Genomforschung, Greifswald, Germany.
Front Med (Lausanne). 2018 Feb 5;5:17. doi: 10.3389/fmed.2018.00017. eCollection 2018.
Circulating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets and platelets exposing signals to mediate their clearance. Thereby, we emphasize the impact of platelet turnover as an important condition for platelet production . Understanding of the features that characterize platelet subpopulations is very relevant for the methods of platelet concentrate production, which may enrich or deplete particular platelet subpopulations. Moreover, the concept of platelet size being associated with platelet function may be attractive for transfusion medicine as it holds the perspective to separate platelet subpopulations with specific functional capabilities.
循环血小板由具有不同年龄、成熟状态和大小的亚群组成。在本综述中，我们探讨了血小板大小与血小板功能之间的关联，并总结了目前关于血小板亚群的知识，包括网织血小板、促凝血小板以及暴露信号以介导其清除的血小板。因此，我们强调血小板更新作为血小板生成的重要条件所产生的影响。了解血小板亚群的特征对于血小板浓缩物的生产方法非常重要，因为这些方法可能会富集或耗尽特定的血小板亚群。此外，血小板大小与血小板功能相关的概念可能对输血医学具有吸引力，因为它有望分离出具有特定功能的血小板亚群。
