Department of Neurology, Charité - University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Department of Radiology, Charité - University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Eur Radiol. 2018 Aug;28(8):3347-3354. doi: 10.1007/s00330-017-5269-y. Epub 2018 Feb 19.
To apply three-dimensional multifrequency MR-elastography (3DMRE) for the measurement of local cerebral viscoelasticity changes in patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP).
T1-weighted anatomical imaging and 3DMRE were performed in 17 PD and 20 PSP patients as well as 12 controls. Two independent viscoelasticity parameters, |G*| and φ, were reconstructed combining seven harmonic vibration frequencies (30-60 Hz). Spatially averaged values were compared by one-way ANOVA, groups were compared using unpaired t test and Mann-Whitney test, respectively. Correlation between clinical data and parameters of brain elasticity and volume were calculated by Pearson's correlation coefficient.
In patients, |G*| was significantly reduced in the frontal and mesencephalic regions (p < 0.05). Beyond that, reduced mesencephalic |G*| discriminated PSP from PD (p < 0.05). Neurodegeneration causes significant brain atrophy (p < 0.01) and is pronounced in PSP patients (p < 0.05 vs. PD). Reduced brain viscoelasticity is correlated with brain atrophy in PSP (r=0.64, p=0.002) and PD (r=0.65, p=0.005) patients but not in controls.
MRE-measured viscoelasticity reflects local structural changes of brain tissue in PSP and in PD and provides a useful parameter to differentiate neurodegenerative movement disorders based on imaging examinations.
• 3D multifrequency MR-elastography reveals diffuse regional changes in brain viscoelasticity in neurodegenerative disorders. • Reduced mesencephalic viscoelasticity separates PD and PSP. • Reduced brain viscoelasticity and brain atrophy as independent hallmarks of neurodegeneration hypothesized.
应用三维多频磁共振弹性成像（3DMRE）测量帕金森病（PD）和进行性核上性麻痹（PSP）患者局部脑粘弹性变化。
对 17 例 PD 患者、20 例 PSP 患者和 12 例对照者进行 T1 加权解剖成像和 3DMRE。结合 7 个谐波振动频率（30-60Hz）重建两个独立的粘弹性参数 |G*|和φ。采用单因素方差分析比较各组间的平均值，分别采用独立样本 t 检验和 Mann-Whitney 检验比较组间差异。通过 Pearson 相关系数计算脑弹性和体积参数与临床数据之间的相关性。
患者的额部和中脑部 |G*|明显降低（p<0.05）。此外，中脑部位的 |G*|降低可将 PSP 与 PD 区分开（p<0.05）。神经退行性变导致显著的脑萎缩（p<0.01），在 PSP 患者中更为明显（p<0.05 与 PD 患者相比）。脑粘弹性降低与 PSP （r=0.64，p=0.002）和 PD （r=0.65，p=0.005）患者的脑萎缩相关，但与对照组无关。
MRE 测量的粘弹性反映了 PSP 和 PD 中脑组织的局部结构变化，并为基于影像学检查的神经退行性运动障碍提供了一种有用的鉴别参数。
3D 多频磁共振弹性成像显示神经退行性疾病中脑粘弹性的弥漫性区域性变化。
中脑粘弹性降低可区分 PD 和 PSP。
脑粘弹性降低和脑萎缩被假设为神经退行性变的独立标志物。
