Streitberger Kaspar-Josche, Fehlner Andreas, Pache Florence, Lacheta Anna, Papazoglou Sebastian, Bellmann-Strobl Judith, Ruprecht Klemens, Brandt Alexander, Braun Jürgen, Sack Ingolf, Paul Friedemann, Wuerfel Jens
Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Eur Radiol. 2017 May;27(5):2206-2215. doi: 10.1007/s00330-016-4561-6. Epub 2016 Aug 29.
Application of multifrequency magnetic resonance elastography (MMRE) of the brain parenchyma in patients with neuromyelitis optica spectrum disorder (NMOSD) compared to age matched healthy controls (HC).
15 NMOSD patients and 17 age- and gender-matched HC were examined using MMRE. Two three-dimensional viscoelastic parameter maps, the magnitude |G*| and phase angle φ of the complex shear modulus were reconstructed by simultaneous inversion of full wave-field data in 1.9-mm isotropic resolution at 7 harmonic drive frequencies from 30 to 60 Hz.
In NMOSD patients, a significant reduction of |G*| was observed within the white matter fraction (p = 0.017), predominantly within the thalamic regions (p = 0.003), compared to HC. These parameters exceeded the reduction in brain volume measured in patients versus HC (p = 0.02 whole-brain volume reduction). Volumetric differences in white matter fraction and the thalami were not detectable between patients and HC. However, phase angle φ was decreased in patients within the white matter (p = 0.03) and both thalamic regions (p = 0.044).
MMRE reveals global tissue degeneration with accelerated softening of the brain parenchyma in patients with NMOSD. The predominant reduction of stiffness is found within the thalamic region and related white matter tracts, presumably reflecting Wallerian degeneration.
• Magnetic resonance elastography reveals diffuse cerebral tissue changes in patients with NMOSD. • Premature tissue softening in NMOSD patients indicates tissue degeneration. • Hypothesis of a widespread cerebral neurodegeneration in form of diffuse tissue alteration.
将视神经脊髓炎谱系障碍（NMOSD）患者脑实质的多频磁共振弹性成像（MMRE）应用于年龄匹配的健康对照（HC）。
使用MMRE对15例NMOSD患者和17例年龄及性别匹配的HC进行检查。通过在1.9毫米各向同性分辨率下，对30至60赫兹的7个谐波驱动频率的全波场数据进行同步反演，重建了两个三维粘弹性参数图，即复剪切模量的大小|G*|和相位角φ。
与HC相比，在NMOSD患者中，观察到白质部分的|G*|显著降低（p = 0.017），主要是在丘脑区域（p = 0.003）。这些参数超过了患者与HC相比测量的脑体积减少量（全脑体积减少p = 0.02）。患者和HC之间白质部分和丘脑的体积差异不可检测。然而，患者白质内（p = 0.03）和两个丘脑区域（p = 0.044）的相位角φ降低。
MMRE显示NMOSD患者脑实质出现整体组织退化并加速软化。硬度的主要降低发生在丘脑区域和相关白质束内，可能反映华勒氏变性。
• 磁共振弹性成像揭示了NMOSD患者的弥漫性脑组织变化。• NMOSD患者过早的组织软化表明组织退化。• 以弥漫性组织改变形式存在广泛脑神经元变性的假说。
