Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, P. R. China.
Phytochem Anal. 2018 Jul;29(4):331-340. doi: 10.1002/pca.2752. Epub 2018 Feb 19.
Panax ginseng has received much attention as a valuable health supplement with medicinal potential. Its chemical diversity and multiple pharmacological properties call for comprehensive methods to better understand the effects of ginseng and ginsenosides. Liquid chromatography-mass spectrometry (LC-MS) based metabonomic approaches just fit the purpose.
Aims to give a review of recent progress on LC-MS based pharmacokinetic, metabolic, and phytochemical metabolomic studies of ginseng, and metabonomic studies of ginseng intervention effects.
The review has four sections: the first section discusses metabolic studies of ginsenosides based on LC-MS, the second focuses on ginsenoside-drug interactions and pharmacokinetic interaction between herb compounds based on LC-MS, the third is phytochemical metabolomic studies of ginseng based on LC-MS, and the fourth deals with metabonomic studies of ginseng intervention effects based on LC-MS.
LC-MS based metabonomic research on ginseng include analysis of single ginsenoside and total ginsenosides. The theory of multi-components and multi-targeted mechanisms helps to explain ginseng effects.
LC-MS based metabonomics is a promising way to comprehensively assess ginseng. It is valuable for quality control and mechanism studies of ginseng.
人参作为一种具有药用潜力的有价值的保健品备受关注。其化学多样性和多种药理特性需要综合的方法来更好地了解人参和人参皂苷的作用。基于液相色谱-质谱（LC-MS）的代谢组学方法正好符合这一目的。
综述基于 LC-MS 的人参药代动力学、代谢和植物化学代谢组学研究以及人参干预作用的代谢组学研究的最新进展。
综述分为四个部分：第一部分讨论了基于 LC-MS 的人参中人参皂苷的代谢研究，第二部分重点讨论了基于 LC-MS 的人参皂苷-药物相互作用和草药化合物的药代动力学相互作用，第三部分是基于 LC-MS 的人参植物化学代谢组学研究，第四部分是基于 LC-MS 的人参干预作用的代谢组学研究。
基于 LC-MS 的人参代谢组学研究包括单一人参皂苷和总人参皂苷的分析。多成分多靶点机制理论有助于解释人参的作用。
基于 LC-MS 的代谢组学是全面评估人参的一种有前途的方法。它对于人参的质量控制和机制研究具有重要价值。
