Hadlow W J, Race R E
Vet Pathol. 1986 Sep;23(5):543-9. doi: 10.1177/030098588602300501.
Widespread spongiform degeneration of the cerebral cortex occurred in four African pygmy goats that became affected with scrapie after intracerebral inoculation with scrapie virus (Suffolk sheep brain origin) that had been passed three times in ranch mink. The occurrence of such cerebrocortical degeneration was a distinct departure from the topographic pattern of neuropathologic changes that characterizes scrapie in sheep and goats. But the cortical lesion was identical to the one found in goats that became affected with a disease otherwise indistinguishable from scrapie after intracerebral inoculation with transmissible mink encephalopathy (TME) virus that had been passed twice in mink. If TME originated from infection with wild scrapie virus, as is generally thought, then the viruses used in these two instances would be equivalent in their passage history in this aberrant host. Given this similarity, the common occurrence of the cortical lesion is thought to be consistent with the view that TME virus almost certainly is scrapie virus whose biologic properties became altered by chance passage in ranch mink.
4只非洲侏儒山羊在脑内接种了已在牧场水貂体内传代3次的羊瘙痒病病毒（源自萨福克绵羊脑）后感染了瘙痒病，其大脑皮质出现了广泛的海绵状变性。这种脑皮质变性的出现明显不同于绵羊和山羊瘙痒病所特有的神经病理变化的地形学模式。但该皮质病变与在脑内接种了已在水貂体内传代2次的传染性水貂脑病（TME）病毒后感染了一种在其他方面与瘙痒病无法区分的疾病的山羊中发现的病变相同。如果TME如普遍认为的那样起源于野生瘙痒病病毒感染，那么在这两种情况下使用的病毒在这种异常宿主中的传代历史将是等效的。鉴于这种相似性，皮质病变的常见出现被认为与以下观点一致，即TME病毒几乎肯定是瘙痒病病毒其生物学特性因在牧场水貂中的偶然传代而发生了改变。
