Hadlow W J, Kennedy R C, Race R E, Eklund C M
Vet Pathol. 1980 Mar;17(2):187-99. doi: 10.1177/030098588001700207.
Virologic and neurohistologic findings in three dairy goats that became affected with scrapie while living with naturally infected Suffolk sheep were essentially like those in affected sheep. Virus, detected by mouse inoculation, was widespread in non-neural sites, particularly in lymphatic tissues and intestine. Im most sites, titers of virus ranged from 3.0 to 3.5 log10 mouse intracerebral LD50/30 mg of tissue. Virus was in nervous tissue in much higher titer. Ranging from 5.1 to 5.8 log10, the highest mean titers were in the diencephalon, midbrain, medulla oblongata and cerebellar cortex--sites of the most severe histologic changes. Although these changes were like those in naturally affected Suffolk sheep, they differed somewhat from those in goats affected with the experimental disease. Spongiform alteration of neuropil was minimal, and the more rostral parts of the brain, such as corpus striatum, globus pallidus and septal area, had few changes. Concentrations and distribution of virus in non-neural tissues were consistent with the conclusion that scrapie virus no doubt can be maintained by contagion in a herd of goats living apart from infected sheep.
三只与自然感染羊瘙痒病的萨福克羊生活在一起并感染羊瘙痒病的奶山羊的病毒学和神经组织学发现，基本上与受感染绵羊的情况相似。通过小鼠接种检测到的病毒在非神经部位广泛存在，尤其是在淋巴组织和肠道。在大多数部位，病毒滴度范围为3.0至3.5 log10小鼠脑内半数致死量/30毫克组织。病毒在神经组织中的滴度要高得多。平均滴度最高，范围为5.1至5.8 log10，出现在间脑、中脑、延髓和小脑皮质——这些部位是组织学变化最严重的地方。尽管这些变化与自然感染的萨福克羊的变化相似，但与实验性疾病感染的山羊的变化略有不同。神经纤维网的海绵状改变很轻微，大脑较靠前的部分，如纹状体、苍白球和隔区，几乎没有变化。病毒在非神经组织中的浓度和分布与以下结论一致：羊瘙痒病病毒无疑可以通过接触在与感染绵羊分开生活的山羊群中传播。
