长链非编码 RNA HOTAIR 多态性与中国人群头颈部鳞状细胞癌易感性的关联。
Association on polymorphisms in LncRNA HOTAIR and susceptibility to HNSCC in Chinese population.
机构信息
Department of Stomatology, Beijing Luhe Hospital Capital Medical University, Beijing, China.
出版信息
Eur Rev Med Pharmacol Sci. 2018 Feb;22(3):702-706. doi: 10.26355/eurrev_201802_14296.
OBJECTIVE
More and more evidence has shown that the critical functions of long non-coding RNA (lncRNA) polymorphism in the carcinogenicity mechanism of a variety of cancers. The association between lncRNA HOX transcript antisense intergenic RNA (HOTAIR) polymorphism and the risk of head and neck squamous cell carcinoma (HNSCC) in Chinese population has not been reported. To investigated the effects of HOTAIR polymorphism on cancer susceptibility, the influence of HOTAIR variants on the risk of HNSCC was analyzed in this study.
PATIENTS AND METHODS
In this case-control study, the tagging SNPs (rs874945, rs4759314, and rs7958904) in HOTAIR gene were genotyped in Chinese population consisting of 366HNSCC cases and 732 controls.
RESULTS
It was found that rs4759314 was associated with a significantly increased risk of HNSCC in Chinese population [GG vs. AA: adjusted odds ratio (OR) = 1.23, 95% confidence interval (CI) = 1.01-1.50; additive model: OR = 1.21, 95%CI = 1.01-1.46]. However, there were no significant associations of rs874945 and rs7958904 with HNSCC risk.
CONCLUSIONS
HOTAIR rs4759314 may influence HNSCC susceptibility and serve as a diagnostic biomarker.
目的
越来越多的证据表明，长链非编码 RNA（lncRNA）多态性在多种癌症的致癌机制中具有关键作用。HOX 转录反义基因间 RNA（HOTAIR）多态性与中国人群头颈部鳞状细胞癌（HNSCC）风险之间的关联尚未报道。为了研究 HOTAIR 多态性对癌症易感性的影响，本研究分析了 HOTAIR 变体对 HNSCC 风险的影响。
患者和方法
在这项病例对照研究中，对 HOTAIR 基因中的标签 SNP（rs874945、rs4759314 和 rs7958904）在中国人群（366 例 HNSCC 病例和 732 例对照）中进行了基因分型。
结果
研究发现，rs4759314 与中国人群 HNSCC 的发病风险显著相关[GG 与 AA：调整后的优势比（OR）=1.23，95%置信区间（CI）=1.01-1.50；加性模型：OR=1.21，95%CI=1.01-1.46]。然而，rs874945 和 rs7958904 与 HNSCC 风险之间没有显著关联。
结论
HOTAIR rs4759314 可能影响 HNSCC 的易感性，并可作为一种诊断生物标志物。
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