Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates.
Coastside Bio Resources, Deer Isle, ME 04627, USA.
Mar Drugs. 2018 Feb 19;16(2):64. doi: 10.3390/md16020064.
Frondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, . Frondoside A has a broad spectrum of anti-cancer effects, including induction of cellular apoptosis, inhibition of cancer cell growth, migration, invasion, formation of metastases, and angiogenesis. In cell lines and animal models studied to date, the anti-cancer effects of the compound are seen in all solid cancers, lymphomas, and leukemias studied to date. These effects appear to be due to potent inhibition of p21-activated kinase 1 (PAK1), which is up-regulated in many cancers. In mouse models, frondoside A has synergistic effects with conventional chemotherapeutic agents, such as gemcitabine, paclitaxel, and cisplatin. Frondoside A administration is well-tolerated. No side effects have been reported and the compound has no significant effects on body weight, blood cells, or on hepatic and renal function tests after long-term administration. Frondoside A may be valuable in the treatment of malignancies, either as a single agent or in combination with other therapeutic modalities.
海参皂苷 A 是一种来自大西洋海参的三萜糖苷。海参皂苷 A 具有广谱的抗癌作用，包括诱导细胞凋亡、抑制癌细胞生长、迁移、侵袭、转移和血管生成。在迄今为止研究的细胞系和动物模型中，该化合物在所有研究过的实体癌、淋巴瘤和白血病中都显示出抗癌作用。这些作用似乎是由于对 p21 激活激酶 1（PAK1）的强烈抑制，PAK1 在许多癌症中上调。在小鼠模型中，海参皂苷 A 与吉西他滨、紫杉醇和顺铂等常规化疗药物具有协同作用。海参皂苷 A 的给药具有良好的耐受性。长期给药后，未报告有副作用，且该化合物对体重、血细胞或肝肾功能试验无明显影响。海参皂苷 A 可能对恶性肿瘤的治疗有价值，无论是作为单一药物还是与其他治疗方式联合使用。
