The PerciaVista Biotechnology Company, Shiraz 71676-83745, Iran.
Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
Mar Drugs. 2023 Apr 28;21(5):283. doi: 10.3390/md21050283.
Lung cancer is one of the most lethal malignancies in the world. However, current curative approaches for treating this type of cancer have some weaknesses. Therefore, scientists are attempting to discover new anti-lung cancer agents. Sea cucumber is a marine-derived source for discovering biologically active compounds with anti-lung cancer properties. To explore the anti-lung cancer properties of sea cucumber, we analyzed surveys using VOSviewer software and identified the most frequently used keywords. We then searched the Google Scholar database for compounds with anti-lung cancer properties within that keyword family. Finally, we used AutoDock 4 to identify the compounds with the highest affinity for apoptotic receptors in lung cancer cells. The results showed that triterpene glucosides were the most frequently identified compounds in studies examining the anti-cancer properties of sea cucumbers. Intercedenside C, Scabraside A, and Scabraside B were the three triterpene glycosides with the highest affinity for apoptotic receptors in lung cancer cells. To the best of our knowledge, this is the first time that anti-lung cancer properties of sea cucumber-derived compounds have been examined in in silico conditions. Ultimately, these three components displayed anti-lung cancer properties in in silico conditions and may be used for the manufacture of anti-lung cancer agents in the near future.
肺癌是世界上最致命的恶性肿瘤之一。然而，目前治疗这种癌症的方法存在一些局限性。因此，科学家们正在试图发现新的抗癌药物。海参是一种海洋来源的物质，可以从中发现具有抗癌特性的生物活性化合物。为了探索海参的抗癌特性，我们使用 Vosviewer 软件分析了调查结果，并确定了最常用的关键词。然后，我们在 Google Scholar 数据库中搜索了该关键词族中具有抗癌特性的化合物。最后，我们使用 AutoDock 4 来确定在肺癌细胞中与凋亡受体结合能力最强的化合物。结果表明，三萜糖苷是研究海参抗癌特性时最常鉴定的化合物。海参苷 C、海参苷 A 和海参苷 B 是与肺癌细胞中凋亡受体结合能力最强的三种三萜糖苷。据我们所知，这是首次在计算机模拟条件下研究海参来源的化合物的抗癌特性。这三种成分在计算机模拟条件下表现出抗癌特性，可能在不久的将来用于制造抗癌药物。
