[将体外分化的肥大细胞移植到小鼠体内]
[Transfer into the mouse of mast cells differentiated in vitro].
作者信息
Schaaf-Lafontaine N, Courtoy R
出版信息
C R Seances Soc Biol Fil. 1986;180(2):234-42.
PMID:2946371
Abstract
A population of mast cells can be derived in vitro by culturing normal spleen cells from C57BL/6 mice with the factor Interleukin 3. These mast cells share the morphological and histochemical features of mast cells at different stages of maturation. We have labelled these in vitro produced mast cells with 111In-Ox and injected them i. v. into normal syngeneic mice. The localisation of labelled cells has been determined 24 and 96 hours after the injection in the spleen, thymus and lymph-nodes.
摘要
通过用白细胞介素3因子培养C57BL/6小鼠的正常脾细胞，可在体外获得一群肥大细胞。这些肥大细胞具有不同成熟阶段肥大细胞的形态和组织化学特征。我们用铟-111标记了这些体外产生的肥大细胞，并将其静脉注射到同基因正常小鼠体内。在注射后24小时和96小时测定了标记细胞在脾脏、胸腺和淋巴结中的定位。
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