Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.
J Hum Hypertens. 2018 Apr;32(4):287-293. doi: 10.1038/s41371-018-0041-6. Epub 2018 Feb 20.
Previous studies have indicated that reactive oxygen species produced by NADPH oxidase (Nox) are important risk factors of hypertension. The current study aims to examine the associations of Nox-related genes with longitudinal blood pressure (BP) changes and the risk of incident hypertension in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) follow-up study. A total of 1,768 participants from 633 families were included in our analysis. Nine BP measurements were obtained in the morning at baseline and during two follow-up visits. The mixed-effect models were used to investigate the associations of 52 tagged single-nucleotide polymorphisms in 11 Nox-related genes with BP changes and incident hypertension. Gene-based analyses were performed by truncated product method (TPM) and Versatile Gene-based Association Study (VEGAS). Over the 7.2 years of follow-up, systolic BP (SBP) and diastolic BP (DBP) increased, and 32.1% (512) of participants developed hypertension. SNPs rs12094228, rs16861188 and rs12066019 in NCF2 were significantly associated with longitudinal change in SBP (P = 1.1 × 10, 2.8 × 10 and 1.2 × 10, respectively). Gene-based analyses revealed that NCF2 was significantly associated with SBP (P = 1.00 × 10, P = 1.26 × 10) and DBP changes (P = 5.84 × 10, P = 1.04 × 10). These findings suggested that NCF2 may play an important role in BP changes over time in the Han Chinese population.
先前的研究表明，NADPH 氧化酶（Nox）产生的活性氧是高血压的重要危险因素。本研究旨在探讨 Nox 相关基因与纵向血压（BP）变化以及遗传流行病学网络中盐敏感性（GenSalt）随访研究中高血压发病风险的关系。我们的分析共纳入了 633 个家庭中的 1768 名参与者。基线和两次随访期间，每天早上共进行了 9 次血压测量。采用混合效应模型来研究 11 个 Nox 相关基因中 52 个标记单核苷酸多态性与 BP 变化和高血压发病的关系。采用截断乘积法（TPM）和多功能基因关联研究（VEGAS）进行基因分析。在 7.2 年的随访期间，收缩压（SBP）和舒张压（DBP）升高，32.1%（512 人）的参与者发生了高血压。NCF2 中的 rs12094228、rs16861188 和 rs12066019 与 SBP 的纵向变化显著相关（P=1.1×10-3、2.8×10-3 和 1.2×10-3）。基因分析显示 NCF2 与 SBP（P=1.00×10-4、P=1.26×10-4）和 DBP 变化显著相关（P=5.84×10-5、P=1.04×10-4）。这些发现表明，在汉族人群中，NCF2 可能在血压随时间的变化中起重要作用。
