Department of Dermatology, University Hospital Schleswig-Holstein, Kiel, Germany.
Exp Dermatol. 2018 May;27(5):489-494. doi: 10.1111/exd.13517. Epub 2018 Apr 10.
Although the role of the microbiota in skin homeostasis is still emerging, there is growing evidence that an intact microbiota supports the skin barrier. The increasing number of research efforts that are trying to shed more light on the human skin-microbiota interaction requires the use of suitable experimental models. Three-dimensional (3D) skin equivalents have been established as a valuable tool in dermatological research because they contain a fully differentiated epidermal barrier that reflects the morphological and molecular characteristics of normal human epidermis. In this review, we provide an overview of current 3D skin models and illustrate the potential of 3D skin models to study the human skin-microbiota interplay.
尽管微生物群在皮肤稳态中的作用仍在不断显现，但越来越多的证据表明，完整的微生物群支持皮肤屏障。越来越多的研究试图更深入地了解人类皮肤-微生物群相互作用，这需要使用合适的实验模型。三维（3D）皮肤等效物已被确立为皮肤科研究中的一种有价值的工具，因为它们包含一个完全分化的表皮屏障，反映了正常人类表皮的形态和分子特征。在这篇综述中，我们概述了当前的 3D 皮肤模型，并说明了 3D 皮肤模型在研究人类皮肤-微生物群相互作用中的潜力。
