Department of Dermatology, Kiel University, Kiel, Germany.
Exp Dermatol. 2020 Nov;29(11):1133-1139. doi: 10.1111/exd.14164. Epub 2020 Aug 27.
In the May issue of Experimental Dermatology 2018, we published a review article focusing on human 3D skin models in the context of microbiota research. The principal intention was to provide an overview of present and future concepts to use skin models in microbiota analyses. With the present viewpoint, we would like to draw the reader's attention again to the use of human skin models in microbiota research with the aim to highlight the benefits and necessity of human skin models to analyse the human skin-microbiota interaction. This is accompanied by a critical view on mice models that often are not suitable to analyse the functional impact of the human skin microbiota. In addition, we present novel and future concepts highlighting the benefits of human 3D skin models in microbiota research.
在 2018 年 5 月的《实验皮肤病学》杂志上，我们发表了一篇综述文章，重点介绍了微生物群研究背景下的人类 3D 皮肤模型。主要目的是提供当前和未来使用皮肤模型进行微生物组分析的概念概述。从目前的观点来看，我们希望再次提请读者注意在微生物组研究中使用人类皮肤模型，目的是强调人类皮肤模型在分析人类皮肤-微生物群相互作用方面的优势和必要性。这伴随着对小鼠模型的批判性看法，因为它们通常不适合分析人类皮肤微生物组的功能影响。此外，我们还提出了新的和未来的概念，强调了人类 3D 皮肤模型在微生物组研究中的优势。
