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基于2-(2'-羟基苯基)苯并咪唑衍生荧光探针的三光气高灵敏高选择性检测

Highly sensitive and selective detection of triphosgene with a 2-(2'-hydroxyphenyl)benzimidazole derived fluorescent probe.

作者信息

Bi Wen-Zhu, Geng Yang, Zhang Wen-Jie, Li Chen-Yu, Ni Chu-Sen, Ma Qiu-Juan, Feng Su-Xiang, Chen Xiao-Lan, Qu Ling-Bo

机构信息

School of Pharmacy, Henan University of Chinese Medicine Zhengzhou China 450046

Henan Engineering Research Center of Modern Chinese Medicine Research, Development and Application Zhengzhou China 450046

出版信息

RSC Adv. 2023 Oct 20;13(44):30771-30776. doi: 10.1039/d3ra06061f. eCollection 2023 Oct 18.

DOI:10.1039/d3ra06061f
PMID:37869386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10587890/
Abstract

In this work, a 2-(2'-hydroxyphenyl)benzimidazole derived fluorescent probe, 2-(2'-hydroxy-4'-aminophenyl)benzimidazole (4-AHBI), was synthesized and its fluorescent behavior toward triphosgene were evaluated. The results showed that 4-AHBI exhibited high sensitivity (limit of detection, 0.08 nM) and excellent selectivity for triphosgene over other acyl chlorides including phosgene in CHCl solution. Moreover, 4-AHBI loaded test strips were prepared for the practical sensing of triphosgene.

摘要

在本研究中，合成了一种2-(2'-羟基苯基)苯并咪唑衍生的荧光探针2-(2'-羟基-4'-氨基苯基)苯并咪唑(4-AHBI)，并评估了其对三光气的荧光行为。结果表明，在CHCl溶液中，4-AHBI对三光气表现出高灵敏度(检测限为0.08 nM)，且对三光气的选择性优于其他酰氯，包括光气。此外，制备了负载4-AHBI的测试条用于三光气的实际传感。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/de7e0a7a2337/d3ra06061f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/fefd5ec6338c/d3ra06061f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/46715757ef24/d3ra06061f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/a0ef2d411eb6/d3ra06061f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/f367223c603d/d3ra06061f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/2486584a553b/d3ra06061f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/71479e1bfed5/d3ra06061f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/0ab4b3e1cc80/d3ra06061f-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/d97121478f4b/d3ra06061f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/de7e0a7a2337/d3ra06061f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/fefd5ec6338c/d3ra06061f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/46715757ef24/d3ra06061f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/a0ef2d411eb6/d3ra06061f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/f367223c603d/d3ra06061f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/2486584a553b/d3ra06061f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/71479e1bfed5/d3ra06061f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/0ab4b3e1cc80/d3ra06061f-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/d97121478f4b/d3ra06061f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb47/10587890/de7e0a7a2337/d3ra06061f-f7.jpg

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