塞尔维亚抗生素管理计划制定经验：其他巴尔干国家的潜在模式？
Experience with developing antibiotic stewardship programs in Serbia: potential model for other Balkan countries?
作者信息
Kalaba Marija, Kosutic Jovan, Godman Brian, Radonjic Vesela, Vujic Ana, Jankovic Slobodan, Srebro Dragana, Kalaba Zlatko, Stojanovic Radan, Prostran Milica
机构信息
Primary Healthcare Centre 'Zemun', Šilerova 46, Belgrade, Serbia.
School of Medicine, University of Belgrade, Belgrade, Serbia.
出版信息
J Comp Eff Res. 2018 Mar;7(3):247-258. doi: 10.2217/cer-2017-0055. Epub 2018 Feb 21.
AIM
Antimicrobial resistance and inappropriate use of antibiotics in children are important issues. Consequently, there is a need to develop comprehensive stewardship programs even in hospitals with limited resources starting with children's hospitals.
METHODS
Retrospective observational analysis of antimicrobial utilization and resistance patterns over 5 years in a tertiary care children's hospital in Serbia.
RESULTS
Cumulative antimicrobial resistance decreased but was still high, with high cumulative resistance rates among the most widely used antibiotics in the hospital. Total antibiotic use decreased from 2010 to 2014 although there was still high prescribing of reserved antibiotics.
CONCLUSION
Concerns with inappropriate use and high resistance rates among some antibiotics used in the hospital are being used to develop guidance on future antibiotic use in this hospital, building on the recently introduced antibiotic stewardship program, as well as encourage other hospitals in Serbia to review their policies.
目的
儿童中的抗菌药物耐药性及抗生素的不当使用是重要问题。因此，即使在资源有限的医院，从儿童医院开始，也有必要制定全面的管理计划。
方法
对塞尔维亚一家三级护理儿童医院5年期间的抗菌药物使用情况及耐药模式进行回顾性观察分析。
结果
累积抗菌药物耐药性有所下降，但仍处于高位，医院中使用最广泛的抗生素的累积耐药率较高。2010年至2014年期间抗生素总使用量有所下降，不过储备抗生素的处方量仍然很高。
结论
基于最近推出的抗生素管理计划，针对医院中一些抗生素的不当使用及高耐药率问题，正在制定该医院未来抗生素使用的指导意见，同时鼓励塞尔维亚的其他医院审查其政策。
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