Lou Xiaoyu, Lu Guanzhen, Zhao Mingming, Jin Peiying
Emergency Department Surgery Department, Huzhou Central Hospital, Huzhou, Zhejiang The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Medicine (Baltimore). 2018 Feb;97(8):e9966. doi: 10.1097/MD.0000000000009966.
Fluid resuscitation was used on aged patients with traumatic shock in their early postoperative recovery. The present study aimed to assess whether different fluid resuscitation strategies had an influence on aged patients with traumatic shock.A total of 219 patients with traumatic shock were recruited retrospectively. Lactated Ringer and hydroxyethyl starch solution were transfused for fluid resuscitation before definite hemorrhagic surgery. Subjects were divided into 3 groups: group A: 72 patients were given aggressive fluid infusion at 20 to 30 mL/min to restore normal mean arterial pressure (MAP) of 65 to 75 mm Hg. Group B: 72 patients were slowly given restrictive hypotensive fluid infusion at 4 to 5 mL/min to maintain MAP of 50 to 65 mm Hg. Group C: 75 patients were given personalized infusion to achieve MAP of 75 to 85 mm Hg. Preoperative infusion volume, preoperative MAP, optimal initial points for surgery, postoperative shock time and mortality rates at 6 and 24 hours after surgery were determined.No significant difference in clinical characteristics was found among the 3 groups. Amount of preoperative infusion was considerably lower in the restrictive group (P < .01, compared with group A). A significant difference in preoperative infusion volume was found between the personalized and other 2 groups (P < .01, compared with groups A and B). Patients in the personalized resuscitation group achieved a higher preoperative MAP (P < .01 compared with Group B; P < .05, compared with group A) and required less prepared time for surgery (P < .01 compared with groups A and B). In addition, a lower mortality rate at 6 and 24 hours after operation was observed in the subjects with personalized therapy (P < .05, compared with group B).Personalized management of fluid resuscitation in traumatized aged patients with appropriate volume and speed of fluid transfusion, suggesting increased survival rate and less prepared time for surgery.
在老年创伤性休克患者术后早期恢复过程中采用了液体复苏。本研究旨在评估不同的液体复苏策略是否对老年创伤性休克患者有影响。回顾性招募了总共219例创伤性休克患者。在确定性出血手术前,输注乳酸林格液和羟乙基淀粉溶液进行液体复苏。将受试者分为3组:A组:72例患者以20至30毫升/分钟的速度进行积极液体输注,以恢复65至75毫米汞柱的正常平均动脉压(MAP)。B组:72例患者以4至5毫升/分钟的速度缓慢进行限制性低血压液体输注,以维持50至65毫米汞柱的MAP。C组:75例患者进行个性化输注,以达到75至85毫米汞柱的MAP。测定术前输注量、术前MAP、最佳手术起始点、术后休克时间以及术后6小时和24小时的死亡率。3组之间临床特征无显著差异。限制性组的术前输注量明显较低(与A组相比,P<0.01)。个性化组与其他两组之间术前输注量存在显著差异(与A组和B组相比,P<0.01)。个性化复苏组患者术前MAP更高(与B组相比,P<0.01;与A组相比,P<0.05),且手术准备时间更短(与A组和B组相比,P<0.01)。此外,接受个性化治疗的受试者术后6小时和24小时的死亡率较低(与B组相比,P<0.05)。对创伤老年患者进行液体复苏的个性化管理,给予适当的输液量和速度,提示可提高生存率并减少手术准备时间。