肌萎缩侧索硬化症患者血清微小 RNA 与临床参数的相关性。
Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis.
机构信息
Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
出版信息
Muscle Nerve. 2018 Aug;58(2):261-269. doi: 10.1002/mus.26106. Epub 2018 Mar 25.
INTRODUCTION
Amyotrophic lateral sclerosis (ALS) is a debilitating neurologic disorder with poor survival rates and no clear biomarkers for disease diagnosis and prognosis.
METHODS
We compared serum microRNA (miRNA) expression from patients with ALS with healthy controls and patients with multiple sclerosis and Alzheimer disease. We also correlated miRNA expression in cross-sectional and longitudinal cohorts of ALS patients with clinical parameters.
RESULTS
We identified 7 miRNAs (miR-192-5p, miR-192-3p, miR-1, miR-133a-3p, miR-133b, miR-144-5p, miR-19a-3p) that were upregulated and 6 miRNAs (miR-320c, miR-320a, let-7d-3p, miR-425-5p, miR-320b, miR-139-5p) that were downregulated in patients with ALS compared with healthy controls, patients with Alzheimer disease, and patients with multiple sclerosis. Changes in 4 miRNAs (miR-136-3p, miR-30b-5p, miR-331-3p, miR-496) correlated positively and change in 1 miRNA (miR-2110) correlated negatively with changes in clinical parameters in longitudinal analysis.
DISCUSSION
Our findings identified serum miRNAs that can serve as biomarkers for ALS diagnosis and progression. Muscle Nerve 58: 261-269, 2018.
简介
肌萎缩侧索硬化症（ALS）是一种使人衰弱的神经系统疾病，生存率低，目前尚无明确的生物标志物用于疾病的诊断和预后。
方法
我们比较了 ALS 患者、多发性硬化症患者和阿尔茨海默病患者的血清微小 RNA（miRNA）表达。我们还将 ALS 患者的横断面和纵向队列中的 miRNA 表达与临床参数相关联。
结果
我们确定了 7 个上调的 miRNA（miR-192-5p、miR-192-3p、miR-1、miR-133a-3p、miR-133b、miR-144-5p、miR-19a-3p）和 6 个下调的 miRNA（miR-320c、miR-320a、let-7d-3p、miR-425-5p、miR-320b、miR-139-5p），与健康对照组、阿尔茨海默病患者和多发性硬化症患者相比，这些 miRNA 在 ALS 患者中上调或下调。4 个 miRNA（miR-136-3p、miR-30b-5p、miR-331-3p、miR-496）的变化与临床参数的变化呈正相关，而 1 个 miRNA（miR-2110）的变化与纵向分析中的临床参数的变化呈负相关。
讨论
我们的研究结果确定了可作为 ALS 诊断和进展的生物标志物的血清 miRNA。《神经肌肉疾病》58: 261-269，2018。
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