酵母 Aim21/Tda2 既通过减少游离端组装来调节游离肌动蛋白，又与 Cap1/Cap2 形成复合物来平衡斑块和电缆之间的肌动蛋白组装。
Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.
机构信息
Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853.
Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
出版信息
Mol Biol Cell. 2018 Apr 15;29(8):923-936. doi: 10.1091/mbc.E17-10-0592. Epub 2018 Mar 30.
Abstract
Yeast Aim21 is recruited by the SH3-containing proteins Bbc1 and Abp1 to patches and, with Tda2, reduces barbed end assembly to balance the distribution of actin between patches and cables. Aim21/Tda2 also interacts with Cap1/Cap2, revealing a complex interplay between actin assembly regulators.
摘要
酵母 Aim21 被含有 SH3 结构域的蛋白质 Bbc1 和 Abp1 募集到斑点处，与 Tda2 一起，减少了突状末端的组装，从而平衡了斑点和电缆之间的肌动蛋白分布。Aim21/Tda2 还与 Cap1/Cap2 相互作用，揭示了肌动蛋白组装调节剂之间的复杂相互作用。
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