Division of Nutritional Science, School of Bioscience, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, England, United Kingdom.
Healthy Mothers, Babies and Children's Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia.
Sci Rep. 2018 Feb 21;8(1):3389. doi: 10.1038/s41598-018-21809-9.
Maternal obesity is associated with prolonged and dysfunctional labour, potentially through decreased synthesis of prostaglandins that stimulate myometrial contractions. We assessed the impact of maternal obesity on concentrations of precursor fatty acids (FA) for prostaglandin synthesis and whether any changes could be reversed by improved nutrition post-conception. Wistar rats were fed control (CON) or High-Fat, High-cholesterol (HFHC) diets 6 weeks before mating. At conception half the dams switched diets providing 4 dietary groups: (1) CON, (2) HFHC, (3) CON-HFHC or (4) HFHC-CON. During parturition rats were euthanized and FA composition of plasma, liver and uterus determined. Visceral fat was doubled in rats exposed to the HFHC diet prior to and/or during pregnancy compared to CON. HFHC diet increased MUFAs but decreased omega-3 and omega-6 PUFAs in plasma and liver. Uterine omega-3 FA concentrations were halved in HFHC versus CON rats, but all other FAs were similar. Switching from HFHC to CON diet at conception restored all FA profiles to those seen in CON rats. The increased MUFA and decreased PUFA concentrations in obese HFHC dams may contribute to aberrant prostaglandin synthesis and dysfunctional myometrial activity and it may be possible to reverse these changes, and potentially improve labour outcomes, by improving nutrition at conception.
母体肥胖与产程延长和功能失调有关，这可能是通过降低刺激子宫收缩的前列腺素合成来实现的。我们评估了母体肥胖对前列腺素合成前体脂肪酸（FA）浓度的影响，以及这些变化是否可以通过受孕后改善营养来逆转。Wistar 大鼠在交配前 6 周接受对照（CON）或高脂肪、高胆固醇（HFHC）饮食。在受孕时，一半的母鼠切换饮食，提供 4 种饮食组：（1）CON，（2）HFHC，（3）CON-HFHC 或（4）HFHC-CON。在分娩期间，处死大鼠并确定血浆、肝脏和子宫中的 FA 组成。与 CON 相比，在怀孕前和/或怀孕期间暴露于 HFHC 饮食的大鼠内脏脂肪增加了一倍。HFHC 饮食增加了 MUFA，但降低了血浆和肝脏中的 omega-3 和 omega-6 PUFAs。与 CON 大鼠相比，HFHC 大鼠的子宫 omega-3 FA 浓度减半，但其他所有 FA 都相似。在受孕时从 HFHC 切换到 CON 饮食可使所有 FA 谱恢复到 CON 大鼠的水平。肥胖的 HFHC 母鼠中 MUFA 的增加和 PUFA 的减少可能导致前列腺素合成异常和子宫肌活动功能失调，通过受孕时改善营养，可能逆转这些变化，并有可能改善分娩结局。
