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利用一种简单的化学传感器在鲶鱼脑中可视化 DCP，一种神经毒剂模拟物。

Visualisation of DCP, a nerve agent mimic, in Catfish brain by a simple chemosensor.

机构信息

Department of Chemistry, Visva-Bharati University, Santiniketan, 731235, India.

Department of Microbiology, University of Calcutta, Kolkata, 700019, India.

出版信息

Sci Rep. 2018 Feb 21;8(1):3402. doi: 10.1038/s41598-018-21780-5.

DOI:10.1038/s41598-018-21780-5
PMID:29467435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5821826/
Abstract

A chemosensor, 3-aminophenol-based rhodamine conjugate (ARC) has been developed for visualisation of diethylchlorophosphate (DCP), mimic of a chemical warfare agent, in Catfish brain. The simple detection of DCP by "turn-on" fluorescence property of the chemosensor makes it unique for easy and rapid in vivo and in vitro detection of DCP with the detection limit of 5.6 nM.

摘要

一种基于 3-氨基酚的罗丹明化学传感器 (ARC) 已被开发用于可视化鲶鱼脑中的二乙基氯膦 (DCP)，DCP 是一种化学战剂的模拟物。该化学传感器具有“开启”荧光性质，可简单检测 DCP，使其具有独特的优势，可用于 DCP 的体内和体外的简便快速检测，检测限为 5.6 nM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/141d251e81e2/41598_2018_21780_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/3f2960c2089b/41598_2018_21780_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/ed2e2ccd14b7/41598_2018_21780_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/05959b6f3258/41598_2018_21780_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/f0c5ee2240c8/41598_2018_21780_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/141d251e81e2/41598_2018_21780_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/3f2960c2089b/41598_2018_21780_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/ed2e2ccd14b7/41598_2018_21780_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/05959b6f3258/41598_2018_21780_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/f0c5ee2240c8/41598_2018_21780_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/5821826/141d251e81e2/41598_2018_21780_Fig5_HTML.jpg

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