Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.
Nat Cell Biol. 2018 Apr;20(4):373-381. doi: 10.1038/s41556-018-0038-y. Epub 2018 Feb 21.
The ability of cells to respond to mechanical forces is critical for numerous biological processes. Emerging evidence indicates that external mechanical forces trigger changes in nuclear envelope structure and composition, chromatin organization and gene expression. However, it remains unclear if these processes originate in the nucleus or are downstream of cytoplasmic signals. Here we discuss recent findings that support a direct role of the nucleus in cellular mechanosensing and highlight novel tools to study nuclear mechanotransduction.
细胞对机械力做出响应的能力对于许多生物学过程至关重要。新出现的证据表明，外部机械力会引发核膜结构和组成、染色质组织和基因表达的变化。然而，这些过程是起源于细胞核还是细胞质信号的下游，目前仍不清楚。本文讨论了支持细胞核在细胞机械感知中起直接作用的最新发现，并强调了研究核力转导的新工具。
